지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 220 - 225 (6page)
이용수
초록· 키워드
오류제보하기
Background: Glucocorticoid receptor β (GRβ) may not bind to ligands and is thought to affect gene transcription only by acting as a dominant negative inhibitor of Glucocorticoid receptor α (GRα). However, there have been few reports about the functional roles of GRβ in the steroid-induces changes of gene expression.
Objective: To investigate the functional role of GRβ overexpression in the steroid- induced changes of gene expression.
Method: The changes in gene expressions such as steroid- induced synthesis of genes, TNF-α-induced synthesis of inflammatory genes and steroid induced suppression of activated genes by TNF-α treatment were compared with and without pCMV GRβ expression.
Result: The number of genes increased by dexamethasonetreatment only in the GRβ transfected group were 54. Increased expressions of genes by dexamethasone treatment were not affected by GRβ overexpression. The number of genes increased by TNF-α treatment only in the GRβ-transfected group were 69. Expressions of genes increased by TNF-α treatment in both the control and the GRβ-transfected group were decreased by further dexamethasone treatment in a similar manner.
Conclusion: The results of this study suggest that GRβ may not be a dominant negative inhibitor in the steroid- induced changes of genes and that it may have some functional roles in the regulation of gene expressions. (Korean J Asthma Allergy Clin Immunol 2008;28: 220-225)
목차
등록된 정보가 없습니다.
참고문헌 (15)
참고문헌 신청
Barnes PJ / 2001 / Molecular mechanisms of corticosteroids in allergic disease / Allergy 56 : 928 ~ 936
Bolstad BM / 2003 / A comparison of normalization methods for high density oligonucleotide array data based on variance and bias / Bioinformatics 22 : 185 ~ 193
Duma D / 2006 / Multiple glucocorticoid receptor isoforms and mechanisms of post-translational modification / J Steroid Biochem Mol Biol 102 : 11 ~ 21
Eisen MB / 1998 / Cluster analysis and display of genome-wide expression patterns / Proc Natl Acad Sci USA 95 : 14863 ~ 14868
Gagliardo R / 2000 / Glucocorticoid receptor alpha and beta in glucocorticoid dependent asthma / Am J Respir Crit Care Med 162 : 7 ~ 13
Bolstad BM / 2003 / A comparison of normalization methods for high density oligonucleotide array data based on variance and bias / Bioinformatics 22 : 185 ~ 193
Duma D / 2006 / Multiple glucocorticoid receptor isoforms and mechanisms of post-translational modification / J Steroid Biochem Mol Biol 102 : 11 ~ 21
Eisen MB / 1998 / Cluster analysis and display of genome-wide expression patterns / Proc Natl Acad Sci USA 95 : 14863 ~ 14868
Gagliardo R / 2000 / Glucocorticoid receptor alpha and beta in glucocorticoid dependent asthma / Am J Respir Crit Care Med 162 : 7 ~ 13
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
GRβ과발현이 스테로이드에 의한 IL-8 합성 및 분비에 미치는 영향
천식 및 알레르기
2005 .01
-
기도상피세포에서 GR 발현이 스테로이드에 의한 전사변화에 미치는 영향
천식 및 알레르기
2003 .01
-
LPS로 유발된 우울증에 대한 감초(甘草)의 효과
대한본초학회지(본초분과학회지)
2014 .01
-
구안와사(말초성 안면신경마비) 입원환자 100례에 대한 임상적 고찰
한방안이비인후피부과학회지
2009 .01
-
Corticosteroid Resistant Asthma
Tuberculosis and Respiratory Diseases
1995 .01
-
Response of Glucocorticoid Receptor Alpha and Histone Deacetylase 2 to Glucocorticoid Treatment Predicts the Prognosis of Sudden Sensorineural Hearing Loss
Clinical and Experimental Otorhinolaryngology
2019 .01
-
척추측만증의 임상적 관찰
대한침구의학회지
2001 .01
-
감초가 면역반응에 미치는 영향 (I) - 50% 메탄올 엑스의 면역조절작용 -
약학회지
1991 .01
-
The comparison of esophageal variceal ligation plus propranolol versus propranolol alone for the primary prophylaxis of esophageal variceal bleedi
Clinical and Molecular Hepatology
2014 .01
-
WTO의 전통지식 등 지적재산권 보호 논의 동향 및 대응 전략의 기본 원칙
한국한의학연구원 논문집
2003 .12
-
Gene Expression Profile and Its Interpretation in Squamous Cell Lung Cancer
Molecular & cellular toxicology
2006 .01
-
A Unique Gene Expression Signature of 5-fluorouracil
Molecular & cellular toxicology
2005 .01
-
마이크로그루브 및 열산화 복합 티타늄 표면의 골아세포분화 증진효과
대한치과보철학회지
2015 .01
-
폐암세포주에서 아데노바이러스 매개 p16 유전자 전달로 인한 유전자 발현의 변화
Toxicological Research
2004 .06
-
폐암세포주에서 아데노바이러스 매개 p16 유전자 전달로 인한 유전자 발현의 변화
Toxicological Research
2004 .03
-
Effect of Hexane Extract of Galla Rhois on Inflammatory Alveolar Bone Loss
International Journal of Oral Biology
2016 .01
-
Neural Mechanisms Underlying Antidepressant-Like Effects of Glycyrrhizae Radix in Rats
동의생리병리학회지
2010 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0