지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 241 - 248 (8page)
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Purpose: To investigate the patterns and risk factors of the ocular manifestations of acquired immunodeficiency syndrome (AIDS) and their correlation with CD4+ count in the era of highly active antiretroviral therapy (HAART).
Methods: This retrospective study examined 127 AIDS patients who presented to Soonchunhyang University Hospital. Data were collected from patient interviews, clinical examinations, and laboratory investigations.
Ophthalmologic examinations included the best-corrected visual acuity, intraocular pressure, anterior segment and adnexal examination, and dilated fundus examination.
Results: Of the 127 patients with AIDS, 118 were on HAART and 9 were not. The mean CD4+ count was 266.7 ± 209.1 cells/μL. There were ocular manifestations in 61 patients (48.0%). The incidence of anterior segment manifestations was higher than posterior segment manifestations at 28.3% and 19.7%, respectively. The mean CD4+ count was significantly (p < 0.05) lower in the patients with posterior versus anterior segment ocular manifestations. The most common ocular manifestation was retinal microvasculopathy (15.0%), followed by keratoconjunctivitis sicca (14.2%), conjunctival microvasculopathy (9.4%), cytomegalovirus retinitis (3.1%), herpes zoster ophthalmicus (2.4%), and blepharitis (1.6%). Retinal microvasculopathy and cytomegalovirus retinitis were common in patients with CD4+ counts <200 cells/μL, while keratoconjunctivitis sicca and conjunctival microvasculopathy were common in patients with CD4+ counts of 200 to 499 cells/μL. There was a significant (p < 0.05) association between ocular manifestation and CD4+ count or age.
Conclusions: The introduction of HAART has changed the landscape of ocular presentations in patients with AIDS. In this study, anterior segment and external ocular manifestations occurred more frequently than posterior segment manifestations. Also, the mean CD4+ count was significantly lower in patients with posterior segment ocular manifestations versus anterior segment ocular manifestations. We found that CD4+ count and age >35 years were independent risk factors for developing ocular manifestations.
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참고문헌 (25)
참고문헌 신청
Acharya NR / 1998 / Corneal, anterior segment, and adnexal manifestations of human immunodeficiency virus / Int Ophthalmol Clin 38 : 161 ~ 177
Ausayakhun S / 2003 / Epidemiology of the ocular complications of HIV infection in Chiang Mai / J Med Assoc Thai 86 : 399 ~ 406
Biswas J / 2002 / Current approaches to di agnosis and management of ocular lesions in human immunodeficiency virus positive patients / Indian J Ophthalmol 50 : 83 ~ 96
Chiou SH / 2000 / Ophthalmic findings in patients with acquired immunodeficiency syndrome / J Microbiol Immunol Infect 33 : 45 ~ 48
Freeman WR / 1984 / A prospective study of the ophthalmologic findings in the acquired immune deficiency syndrome / Am J Ophthalmol 97 : 133 ~ 142
Ausayakhun S / 2003 / Epidemiology of the ocular complications of HIV infection in Chiang Mai / J Med Assoc Thai 86 : 399 ~ 406
Biswas J / 2002 / Current approaches to di agnosis and management of ocular lesions in human immunodeficiency virus positive patients / Indian J Ophthalmol 50 : 83 ~ 96
Chiou SH / 2000 / Ophthalmic findings in patients with acquired immunodeficiency syndrome / J Microbiol Immunol Infect 33 : 45 ~ 48
Freeman WR / 1984 / A prospective study of the ophthalmologic findings in the acquired immune deficiency syndrome / Am J Ophthalmol 97 : 133 ~ 142
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