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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 174 - 182 (9page)
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Background: The trigeminal nucleus caudalis (Vc) is a primary central site for trigeminal transmitting. Noxious stimulation of the trigeminal nociceptors alters the central synaptic releases and neural expression of some inflammatory and trophic agents. Orexin-A and the orexin 1 receptor (OX1R) are expressed in pain pathways including trigeminal pain transmission. However, the the mechanism(s) underling orexin-A effects on trigeminal pain modulation have not been fully clarified.Methods: Trigeminal pain was induced by subcutaneous injection of capsaicin in the upper lip in rats. The effect of trigeminal pain on cyclooxygenase-2 (COX-2) and brain-derived neurotrophic factor (BDNF) expression in the Vc of animals was determined by immunofluorescence. Subsequently, OX1R agonist (orexin-A) and antagonist (SB-334867-A) was administrated in the Vc to investigate the possible roles of the Vc OX1R on changes in COX-2 and BDNF levels following pain induction.Results: The data indicated an increase in COX-2 and decrease in BDNF immuno-reactivity in the Vc of capsaicin, and capsaicin- pretreated with SB-334867-A (80 nM), groups of rat. However, the effect of capsaicin on COX-2 and BDNF expressions was reversed by a Vc microinjection of orexin-A (100 pM).Conclusions: Overall, the present data reveals that orexin-A can attenuate capsaicin-induced trigeminal pain through the modulation of pain effects on COX-2 and BDNF expressions in the Vc of rats. (Korean J Pain 2018; 31: 174-82)
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참고문헌 (45)
참고문헌 신청
Sessle BJ / 1999 / Neural mechanisms and pathways in craniofacial pain / Can J Neurol Sci 26(Suppl 3):S7~S11
Boggero IA / 2016 / Satisfaction with life in orofacial pain disorders: associations and theoretical implications / J Oral Facial Pain Headache 30:99~106
Gao Y / 2010 / Increased COX2 in the trigeminal nucleus caudalis is involved in orofacial pain induced by experimental tooth movement / Anat Rec (Hoboken) 293:485~491
Lee KM / 2004 / Spinal NF-kB activation induces COX-2 upregulation and contributes to inflammatory pain hypersensitivity / Eur J Neurosci 19:3375~3381
Lu Y / 2008 / BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory / Neurobiol Learn Mem 89:312~323
Boggero IA / 2016 / Satisfaction with life in orofacial pain disorders: associations and theoretical implications / J Oral Facial Pain Headache 30:99~106
Gao Y / 2010 / Increased COX2 in the trigeminal nucleus caudalis is involved in orofacial pain induced by experimental tooth movement / Anat Rec (Hoboken) 293:485~491
Lee KM / 2004 / Spinal NF-kB activation induces COX-2 upregulation and contributes to inflammatory pain hypersensitivity / Eur J Neurosci 19:3375~3381
Lu Y / 2008 / BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory / Neurobiol Learn Mem 89:312~323
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