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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 85 - 91 (7page)
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The present study investigated the participation of D-serine and NR2 in antinociception produced by blockade of central erythropoietin-producing hepatocellular carcinoma (Eph) A4 (EphA4) signaling in rats with trigeminal neuropathic pain. Trigeminal neuropathic pain was modeled in male Sprague-Dawley rats using mal-positioned dental implants. The left mandibular second molar was extracted under anesthesia, and a miniature dental implant was placed to induce injury to the inferior alveolar nerve. Our current findings showed that nerve injury induced by malpositioned dental implants significantly produced mechanical allodynia; additionally, the inferior alveolar nerve injury increased the expression of D-serine and NR2 subunits in the ipsilateral medullary dorsal horn (trigeminal subnucleus caudalis). Intracisternal administration of EphA4-Fc, an EphA4 inhibitor, inhibited nerve injury-induced mechanical allodynia and upregulated the expression of D-serine and NR2 subunits. Moreover, intracisternal administration of D-amino acids oxidase, a D-serine inhibitor, inhibited trigeminal mechanical allodynia. These results show that D-serine and NR2 subunit pathways participate in central EphA4 signaling after an inferior alveolar nerve injury. Therefore, blockade of D-serine and NR2 subunit pathways in central EphA4 signaling provides a new therapeutic target for the treatment of trigeminal neuropathic pain.
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참고문헌 (52)
참고문헌 신청
Linda R. Watkins / 2001 / Spinal cord glia: new players in pain / Pain 93(3):201~205
Linda R. Watkins / 2002 / Beyond Neurons: Evidence That Immune and Glial Cells Contribute to Pathological Pain States / Physiological Reviews 82(4):981~1011
R.W. Colburn / 1999 / The Effect of Site and Type of Nerve Injury on Spinal Glial Activation and Neuropathic Pain Behavior / Experimental Neurology 157(2):289~304
Hiroshi Hashizume / 2000 / Spinal Glial Activation and Cytokine Expression After Lumbar Root Injury in the Rat / Spine 25(10):1206~1217
F.Y Tanga / 2004 / Quantitative real-time RT-PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain / Neurochemistry International 45(2-3):397~407
Linda R. Watkins / 2002 / Beyond Neurons: Evidence That Immune and Glial Cells Contribute to Pathological Pain States / Physiological Reviews 82(4):981~1011
R.W. Colburn / 1999 / The Effect of Site and Type of Nerve Injury on Spinal Glial Activation and Neuropathic Pain Behavior / Experimental Neurology 157(2):289~304
Hiroshi Hashizume / 2000 / Spinal Glial Activation and Cytokine Expression After Lumbar Root Injury in the Rat / Spine 25(10):1206~1217
F.Y Tanga / 2004 / Quantitative real-time RT-PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain / Neurochemistry International 45(2-3):397~407
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