지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 149 - 155 (7page)
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초록· 키워드
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Background: Keloids are characterized by excessive collagen deposition in the dermis, in which transforming growth factor β (TGF-β)/Smad signaling plays an important role.
Low-level light therapy (LLLT) is reported as effective in preventing keloids in clinical reports, recently. To date, studies investigating the effect of LLLT on keloid fibroblasts are extremely rare. Objective: We investigated the effect of LLLT with blue (410 nm), red (630 nm), and infrared (830 nm) light on the collagen synthesis in keloid fibroblasts. Methods: Keloid fibroblasts were isolated from keloid-revision surgery samples and irradiated using 410-, 630-, 830-nm light emitting diode twice, with a 24-hour interval at 10 J/cm2. After irradiation, cells were incubated for 24 and 48 hours and real- time quantitative reverse transcription polymerase chain reaction was performed. Western blot analysis was also performed in 48 hours after last irradiation. The genes and proteins of collagen type I, TGF-β1, Smad3, and Smad7 were analyzed. Results: We observed no statistically significant change in the viability of keloid fibroblasts after irradiation.
Collagen type I was the only gene whose expression significantly decreased after irradiation at 410 nm when compared to the non-irradiated control. Western blot analysis showed that LLLT at 410 nm lowered the protein levels of collagen type I compared to the control. Conclusion: LLLT at 410 nm decreased the expression of collagen type I in keloid fibroblasts and might be effective in preventing keloid formation in their initial stage.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Babu M / 1992 / Keloid fibroblasts exhibit an altered response to TGF-beta / J Invest Dermatol 99 : 650 ~ 655
Barolet D / 2010 / Prophylactic low-level light therapy for the treatment of hypertrophic scars and keloids: a case series / Lasers Surg Med 42 : 597 ~ 601
Bonatti S / 2011 / In vitro effect of 470 nm LED (Light Emitting Diode) in keloid fibroblasts / Acta Cir Bras 26 : 25 ~ 30
Carvalho RL / 2010 / Effects of low-level laser therapy on pain and scar formation after inguinal herniation surgery: a randomized controlled single-blind study / Photomed La
Chin GS / 2001 / Differential expression of transforming growth factorbeta receptors I and II and activation of Smad 3 in keloid fibroblasts / Plast Reconstr Surg 108 : 423 ~
Barolet D / 2010 / Prophylactic low-level light therapy for the treatment of hypertrophic scars and keloids: a case series / Lasers Surg Med 42 : 597 ~ 601
Bonatti S / 2011 / In vitro effect of 470 nm LED (Light Emitting Diode) in keloid fibroblasts / Acta Cir Bras 26 : 25 ~ 30
Carvalho RL / 2010 / Effects of low-level laser therapy on pain and scar formation after inguinal herniation surgery: a randomized controlled single-blind study / Photomed La
Chin GS / 2001 / Differential expression of transforming growth factorbeta receptors I and II and activation of Smad 3 in keloid fibroblasts / Plast Reconstr Surg 108 : 423 ~
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