지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 50 - 58 (9page)
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초록· 키워드
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Background and Objectives Low-level light therapy (LLLT) is an application of low-power light for various purposes such as promoting tissue repair, reducing inflammation, causing analgesia, etc. A previous study suggested the effect of light emitting diode (LED) light with the wavelength of 740 nm for promoting wound healing of corneal epithelial cells. This current study aimed to confirm the effect of LLLT for managing inflammation of a dry eye disease (DED) mouse model. Materials and Methods A total of 50C57BL/6 female mice were randomly grouped into 5 groups to compare the effect of LLLT:1) Control group, 2) Only LLLT group, 3) Dry eye group, 4) LLLT in dry eye group, and 5) Early treatment group. DED was induced with 4 daily injections of scopolamine hydrobromide and desiccation stress for 17 days, and LLLT at 740 nm was conducted once every 3 days. To analyze the effect of LLLT on the DED mouse model, tear volume, corneal surface irregularities, and fluorescence in stained cores were measured, and the level of inflammation was assessed with immunohistochemistry. Results The DED mouse model showed significant deterioration in the overall eye condition. After LLLT, the amount of tear volume was increased, and corneal surface irregularities were restored. Also, the number of neutrophils and the level of inflammatory cytokines significantly decreased as well. Conclusion This study showed that LLLT at 740 nm was effective in controlling the corneal conditions and the degree of inflammation in DED. Such findings may suggest therapeutic effects of LLLT at 740 nm on DED.
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참고문헌 (40)
참고문헌 신청
Gayton JL / 2009 / Etiology, prevalence, and treatment of dry eye disease / Clin Ophthalmol 3:405~412
Han SB / 2011 / Prevalence of dry eye disease in an elderly Korean population / Arch Ophthalmol 129:633~638
Stevenson W / 2012 / Dry eye disease: an immune-mediated ocular surface disorder / Arch Ophthalmol 130:90~100
de Paiva CS / 2003 / Assessing the severity of keratitis sicca with videokeratoscopic indices / Ophthalmology 110:1102~1109
Goto E / 2002 / Impaired functional visual acuity of dry eye patients / Am J Ophthalmol 133:181~186
Han SB / 2011 / Prevalence of dry eye disease in an elderly Korean population / Arch Ophthalmol 129:633~638
Stevenson W / 2012 / Dry eye disease: an immune-mediated ocular surface disorder / Arch Ophthalmol 130:90~100
de Paiva CS / 2003 / Assessing the severity of keratitis sicca with videokeratoscopic indices / Ophthalmology 110:1102~1109
Goto E / 2002 / Impaired functional visual acuity of dry eye patients / Am J Ophthalmol 133:181~186
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