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논문 기본 정보

자료유형
학술저널
저자정보
In Kwon Mun (Department of Otolaryngology-Head and Neck Surgery Dankook University College of Medicine Cheonan K) Won Sang Yoo (Department of Internal Medicine Dankook University college of Medicine Cheonan Korea (공1)) Sang Joon Lee (Department of Otolaryngology-Head and Neck Surgery Dankook University College of Medicine Cheonan K) Phil-Sang Chung (Department of Otolaryngology-Head and Neck Surgery Dankook University College of Medicine Cheonan K) Seung Hoon Woo (Department of Otolaryngology-Head and Neck Surgery Dankook University College of Medicine Cheonan K)
저널정보
대한의학레이저학회 MEDICAL LASERS MEDICAL LASERS 제10권 제1호
발행연도
2021.1
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37 - 44 (8page)

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Background and Objectives Hypothyroidism is the most common endocrine disease. On the other hand, there is no treatment that can improve the thyroid function. Lowlevel laser therapy (LLLT) can improve the cellular activity. The effect of hypothyroidism is not obvious. This study examined the effects of LLLT on the thyroid gland function of a propylthiouracil (PTU)-induced hypothyroidism mouse model. Materials and Methods Twenty-five male ICR mice were distributed into five groups of five animals each: Negative control (none PTU animal) and positive control (PTU animal) of unirradiated animals, and three experimental groups with LLLT (3J, 6J, and 12J). Each mouse was exposed to a distinct dose of a 632-nm laser once a week for three rounds. The positive control group and three LLLT groups were induced into a hypothyroidism state by PTU administration. The animals’ thyroid-stimulating hormone and thyroxine levels were measured using an ELISA kit, and their thyroid tissue was harvested and analyzed after sacrifice at the end of the experiment. The hormone level and morphological changes in the tissue of the five groups were compared. Results The thyroid hormone levels in the control group and LLLT groups were similar. On the other hand, the thyroid tissue of the LLLT groups showed some morphological changes that were similar to those of iodine deficiency thyroid. Conclusion LLLT did not affect the thyroid gland function in PTU-induced hypothyroidism mice.

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