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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한악안면성형재건외과학회 Maxillofacial Plastic Reconstructive Surgery Maxillofacial Plastic Reconstructive Surgery 제38권 제11호
- 발행연도
- 2016.11
- 수록면
- 1 - 8 (8page)
- DOI
- 10.1186/s40902-016-0095-8
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초록· 키워드
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Background This study investigates the effect of alendronate-treated osteoblasts, as well as the effect of low-level laser therapy (LLLT) on the alendronate-treated osteoblasts. Bisphosphonate decreases the osteoblastic activity. Various treatment modalities are used to enhance the bisphosphonate-treated osteoblasts; however, there were no cell culture studies conducted using a low-level laser.
Methods Human fetal osteoblastic (hFOB 1.19) cells were treated with 50 μM alendronate. Then, they were irradiated with a 1.2 J/cm2 low-level Ga-Al-As laser (λ?=?808?±?3 nm, 80 mW, and 80 mA; spot size, 1 cm2; NDLux, Seoul, Korea). The cell survivability was measured with the MTT assay. The three cytokines of osteoblasts, receptor activator of nuclear factor κB ligand (RANKL), osteoprotegerin (OPG), and macrophage colony-stimulating factor (M-CSF) were analyzed.
Results In the cells treated with alendronate at concentrations of 50 μM and higher, cell survivability significantly decreased after 48 h (p?<?0.05). After the applications of low-level laser on alendronate-treated cells, cell survivability significantly increased at 72 h (p?<?0.05). The expressions of OPG, RANKL, and M-CSF have decreased via the alendronate. The RANKL and M-CSF expressions have increased, but the OPG was not significantly affected by the LLLT.
Conclusions The LLLT does not affect the OPG expression in the hFOB cell line, but it may increase the RANKL and M-CSF expressions, thereby resulting in positive effects on osteoclastogenesis and bone remodeling.
목차
등록된 정보가 없습니다.
참고문헌 (44)
참고문헌 신청
Rogers MJ / 1997 / Overview of bisphosphonates / Cancer 80(8 Suppl):1652~1660
Coleman RE / 2002 / Setting new standards in bisphosphonates therapy / Am J Clin Oncol 25(6 Suppl 1):S1~S2
Marx RE / 2003 / Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic / J Oral Maxillofac Surg 61(9):1238~1239
Ruggiero SL / 2004 / Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases / J Oral Maxillofac Surg 62(5):527~534
Subramanian G / 2011 / A model for the pathogenesis of bisphosphonate-associated osteonecrosis of the jaw and teriparatide's potential role in its resolution / Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112(6):744~753
Coleman RE / 2002 / Setting new standards in bisphosphonates therapy / Am J Clin Oncol 25(6 Suppl 1):S1~S2
Marx RE / 2003 / Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic / J Oral Maxillofac Surg 61(9):1238~1239
Ruggiero SL / 2004 / Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases / J Oral Maxillofac Surg 62(5):527~534
Subramanian G / 2011 / A model for the pathogenesis of bisphosphonate-associated osteonecrosis of the jaw and teriparatide's potential role in its resolution / Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112(6):744~753
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