지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.6
- 수록면
- 460 - 468 (9page)
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초록· 키워드
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Purpose: Diabetes is a risk factor for periodontal disease and can cause alveolar bone loss. The purpose of this study was to explore the effect of diabetes on homeostatic factor of periodontal tissue using leptin receptor (db/db) mice.
Materials and Methods: The db/db mice(experimental group) were compared with the wild type mice (control group) using histology and immunohistochemical analyses. Collagen fibers were evaluated using H&E, picrosirius red, fibromodulin staining and osteogenic factors (periostin, osteopontin, osteocalcin, osterix), and factors related to osteoclasts (OPG, RANKL) in the PDL were investigated.
Results: Collagen fibers and osteogenic factors in the PDL showed no differences between a control and an experimental group. In an experimental group, expression of receptor activator of nuclear factor kappa-B ligand (RANKL) was similar compared with a control group, while expression of osteoprotegerin (OPG) was decreased.
Conclusions: RANKL/OPG ratio may be one of homeostatic factors related to bone remodeling in diabetic mice.
Materials and Methods: The db/db mice(experimental group) were compared with the wild type mice (control group) using histology and immunohistochemical analyses. Collagen fibers were evaluated using H&E, picrosirius red, fibromodulin staining and osteogenic factors (periostin, osteopontin, osteocalcin, osterix), and factors related to osteoclasts (OPG, RANKL) in the PDL were investigated.
Results: Collagen fibers and osteogenic factors in the PDL showed no differences between a control and an experimental group. In an experimental group, expression of receptor activator of nuclear factor kappa-B ligand (RANKL) was similar compared with a control group, while expression of osteoprotegerin (OPG) was decreased.
Conclusions: RANKL/OPG ratio may be one of homeostatic factors related to bone remodeling in diabetic mice.
목차
ABSTRACT
Ⅰ. 서론
Ⅱ. 재료 및 방법
Ⅲ. 결과
Ⅳ. 고찰
Ⅴ. 이해상충
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