지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.3
- 수록면
- 276 - 284 (9page)
이용수
초록· 키워드
오류제보하기
Purpose: Phosphatase and tension homolog (PTEN) has been known to play a role of maintenance of homeostasis over the body. It is little known about the roles of PTEN in periodontal complex. The purpose of this study was to explore the role of PTEN in periodontal complexes after removing PTEN from osteoblasts and odontoblasts.
Materials and Methods: The resulting OCN-Cretg/+;Ptenfl/fl mice were created after by conditionally eliminating the PTEN gene using an Osteocalcin (OCN) Cre driver and the resulting OCN-Cretg/+;Ptenfl/fl mice (experimental group) were compared with the wild type mice (control group) using micro-CT, histology and immunohistochemical analyses. The amount of dentin and alveolar bone was analyzed, and osteopontin and bone sialoprotein in the periodontal ligament space (PDL) were evaluated and collagen in the PDL was analyzed quantitatively and qualitatively.
Results: Micro CT showed that dentin and bone were significantly accumulated in an experimental group. Dentin sialoprotein was significantly increase in dentin of an experimental group. Internal balance in the PDL was altered with increased expression of PCNA in an experimental group.
Conclusions: Loss of PTEN causes an increase of dentin and bone in the periodontal complexes with an alteration of internal balance in the PDL. These findings underscore the effect of PTEN on homeostatic control of periodontal complexes.
Materials and Methods: The resulting OCN-Cretg/+;Ptenfl/fl mice were created after by conditionally eliminating the PTEN gene using an Osteocalcin (OCN) Cre driver and the resulting OCN-Cretg/+;Ptenfl/fl mice (experimental group) were compared with the wild type mice (control group) using micro-CT, histology and immunohistochemical analyses. The amount of dentin and alveolar bone was analyzed, and osteopontin and bone sialoprotein in the periodontal ligament space (PDL) were evaluated and collagen in the PDL was analyzed quantitatively and qualitatively.
Results: Micro CT showed that dentin and bone were significantly accumulated in an experimental group. Dentin sialoprotein was significantly increase in dentin of an experimental group. Internal balance in the PDL was altered with increased expression of PCNA in an experimental group.
Conclusions: Loss of PTEN causes an increase of dentin and bone in the periodontal complexes with an alteration of internal balance in the PDL. These findings underscore the effect of PTEN on homeostatic control of periodontal complexes.
목차
ABSTRACT
Ⅰ. 서론
Ⅱ. 재료 및 방법
Ⅲ. 결과
Ⅳ. 고찰
참고문헌
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Prognostic Role of PTEN Gene Expression and Length of Survival of Breast Cancer Patients in the North East of Iran
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
PTEN Methylation Dependent Sinonasal Mucosal Melanoma
Cancer Research and Treatment
2016 .01
-
Prognostic Role of PTEN Gene Expression in Breast Cancer Patients from North-East Iran
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Loss of Expression of PTEN is Associated with Worse Prognosis in Patients with Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Effect of PTEN Polymorphism on the Development of Hepatitis B Virus-associated Hepatocellular Carcinoma
Journal of Liver Cancer
2019 .01
-
The Smad4/PTEN Expression Pattern Predicts Clinical Outcomes in Colorectal Adenocarcinoma
Journal of Pathology and Translational Medicine
2018 .01
-
Association of the PTEN IVS4 (rs3830675) Gene Polymorphism with Reduced Risk of Cancer: Evidence from a Meta-analysis
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Predictive and Prognostic Significance of p27, Akt, PTEN and PI3K Expression in HER2-Positive Metastatic Breast Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
PTEN Mutation Identified in Patient Diagnosed with Simultaneous Multiple Cancers
Cancer Research and Treatment
2019 .01
-
Role of exon 7 PTEN Gene in Endometrial Carcinoma
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
MicroRNA-552 expression in colorectal cancer and its clinicopathological significance
Journal of Pathology and Translational Medicine
2021 .01
-
3-D Printing Approaches for Periodontal Complex Regeneration : Bone-PDL-Cementum
대한치과재료학회 학술대회
2016 .04
-
Prediction and Analysis of Breast Cancer Related Deleterious Non-Synonymous Single Nucleotide Polymorphisms in the PTEN Gene
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Evaluation of PTEN Inhibitor Following Spinal Cord Injury on Recovery of Voiding Efficiency and Motor Function Observed by Regeneration in Spinal Cord
International Neurourology Journal
2020 .01
-
Expression of Phosphatase and Tensin Homologue, phospho-Akt, and p53 in Acral Benign and Malignant Melanocytic Neoplasms (Benign Nevi, Dysplastic Nevi, and Acral Melanomas)
Annals of Dermatology
2016 .01
-
Conditional PTEN-deficient Mice as a Prostate Cancer Chemoprevention Model
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Accuracy of three-dimensional periodontal ligament models generated using cone-beam computed tomography at different resolutions for the assessment of periodontal bone loss
대한치과교정학회지
2023 .03
-
Modulation of PI3K signaling by PTEN and mTOR complex 2 in germinal center B cells and antibody production
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Ginkgetin blocks constitutive STAT3 activation and induces apoptosis through induction of SHP-1 and PTEN tyrosine phosphatases
대한동의병리학회 학술대회논문집
2015 .10
-
제2형 당뇨모델 생쥐에서 치주인대조직 내 항상성조절인자 변화: 예비연구
대한치과의사협회지
2023 .06
이 논문의 저자 정보
이 논문과 함께 이용한 논문
매생이 추출물 첨가 통밀 쿠키의 마우스 혈당 항상성 개선 효과
임재민
,
전수현
,
정유진
외 1명
한국식품과학회지
2021
.06
PCR을 이용한 인간 세포거대바이러스(HCMV) DNA 중합효소 유전자의 검색
김현철
,
박성배
,
조원현
외 2명
The Journal of the Korean Society for Microbiology
1992
.04
생체 항상성 유지를 위한 식생활의 역할
강미영
한국생명과학회 심포지움
2004
.05
재조합효소-중합효소 증폭법(RPA) 및 중합효소 연쇄반응법(PCR)에서 생성된 특이 DNA 증폭산물 간의 비교
김정민
,
임수진
,
Tai A T
외 4명
Journal of Apiculture
2017
.04
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2023-515-001319915