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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 269 - 274 (6page)
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Background: Reconstructed human epidermal culture skin models have been developed for cosmetic and pharmaceutical research. Objective: This study evaluated the total and carboxyl esterase activities (i.e., Km and Vmax, respectively) and localization in two reconstructed human epidermal culture skin models (LabCyte EPI-MODEL [Japan Tissue Engineering] and EpiDerm [MatTek/Kurabo]). The usefulness of the reconstruction cultured epidermis was also verified by comparison with human and rat epidermis. Methods: Homogenized epidermal samples were fractioned by centrifugation. p-nitrophenyl acetate and 4-methylumbelliferyl acetate were used as substrates of total esterase and carboxyl esterase, respectively. Results: Total and carboxyl esterase activities were present in the reconstructed human epidermal culture skin models and were localized in the cytosol. Moreover, the activities and localization were the same as those in human and rat epidermis. Conclusion: LabCyte EPI-MODEL and EpiDerm are potentially useful for esterase activity prediction in human epidermis.
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참고문헌 (23)
참고문헌 신청
Alexson SE / 2002 / Involvement of liver carboxylesterases in the in vitro metabolism of lidocaine / Drug Metab Dispos 30 : 643 ~ 647
Batz FM / 2013 / Esterase activity in excised and reconstructed human skin--biotransformation of prednicarbate and the model dye fluorescein diacetate / Eur J Pharm Biopharm
Bhatt RH / 1997 / Determination and correlation of in vitro viability for hairless mouse and human neonatal whole skin and stratum corneum/epidermis / Arch Dermatol Res 289
Boehnlein J / 1994 / Characterization of esterase and alcohol dehydrogenase activity in skin. Metabolism of retinyl palmitate to retinol (vitamin A)during percutaneous absor
Clark NW / 1993 / Fate of fluazifop butyl in rat and human skin in vitro / Arch Toxicol 67 : 44 ~ 48
Batz FM / 2013 / Esterase activity in excised and reconstructed human skin--biotransformation of prednicarbate and the model dye fluorescein diacetate / Eur J Pharm Biopharm
Bhatt RH / 1997 / Determination and correlation of in vitro viability for hairless mouse and human neonatal whole skin and stratum corneum/epidermis / Arch Dermatol Res 289
Boehnlein J / 1994 / Characterization of esterase and alcohol dehydrogenase activity in skin. Metabolism of retinyl palmitate to retinol (vitamin A)during percutaneous absor
Clark NW / 1993 / Fate of fluazifop butyl in rat and human skin in vitro / Arch Toxicol 67 : 44 ~ 48
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