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학술저널
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대한피부과학회 Annals of Dermatology Annals of Dermatology 제22권 제1호
발행연도
2010.1
수록면
9 - 15 (7page)

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Background: Steroids are used in conventional treatment of atopic dermatitis (AD) and they are very effective for improving the symptoms, but they also have several complications. Many studies have reported that short-term use of cyclosporine (CsA) is effective for severe AD as a substitute for steroid. However, there are very few studies on the long-term use of CsA for AD in the Korean population. Objective: The purpose of this study was to investigate whether long-term CsA therapy is effective and safe for treating AD. Methods: We performed a retrospective study of the patients with AD and who were treated with CsA at Kyung Hee Medical Center between January 2001 and February 2008. Among 147 patients, 61 received CsA treatment for more than 6 months. To evaluate the efficacy of CsA treatment, the objective SCORAD was checked for all 61patients at every visit. Extensive laboratory tests were performed every two months to assess the safety of treatment. Results: The mean duration of CsA treatment was 13.5±8.4months and the mean initial dose of CsA was 2.7±0.9mg/kg/day. The mean objective SCORAD values significantly decreased from 34.1±11.2 at baseline to 11.4±10.7after 6-month of CsA treatment (p＜0.05). A significant decline of the SCORAD score was observed starting from 1-month of CsA treatment. The mean duration of remission was 4.5±2.9 months. A total of 13 adverse events in 10patients were recorded during the study period. One patient dropped out due to renal dysfunction. Elevation of peripheral blood pressure was noted in 8 patients. Three patients complained of gastrointestinal troubles, and one patient had hypertrichosis, but the problems of these 4 patients were mild and easily treated. Conclusion: We suggest that longterm,low-dose CsA treatment is safe and effective for patients who suffer from AD. (Ann Dermatol 22(1) 9∼15, 2010)
#Atopic dermatitis #Cyclosporine #Long-term treatment

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참고문헌 (25)

참고문헌 신청
Borel JF / 1976 / Biological effects of cyclosporin A:a new antilymphocytic agent / Agents Actions 6 : 468 ~ 475 google schola Bunikowski R / 2001 / Low-dose cyclosporin A microemulsion in children with severe atopic dermatitis:clinical and immunological effects / Pediatr Allergy Immunol 12 : 216 ~ google schola Campbell DE / 1997 / Cyclosporine restores cytokine imbalance in childhood atopic dermatitis / J Allergy Clin Immunol 99 : 857 ~ 859 google schola Chobanian AV / 2003 / The Seventh Report of the Joint National Committee on Prevention,Detection,Evaluation,and Treatment of High Blood Pressure:the JNC 7 report / JAMA 289 google schola Eynott PR / 2003 / Effects of cyclosporin A and a rapamycin derivative(SAR943)on chronic allergic inflammation in sensitized rats / Immunology 109 : 461 ~ 467 google schola

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