지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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This review summarizes gender differences in pharmacokinetics, pharmacodynamics, and adverse drug reactions. Gender differences in pharmacokinetics are categorized by four major factors: absorption/bioavailability, distribution, metabolism,and elimination. There are sex-based differences in gastric emptying time, gastric alcohol dehydrogenase activity,apparent volume of distribution, α1-acid glycoprotein level, phase I (CYP) and phase II metabolizing enzymes, glomerular filtration rate, and drug transporters. This review also reports gender differences in pharmacokinetics and pharmacodynamics of cardiovascular agents, central nervous system acting agents and antiviral agents. In addition, it has been reported that females experience more adverse reactions such as coughing, tachycardia, nausea, vomiting, rash, hypersensitivity,hepatotoxicity, and metabolic disorder after taking cardiovascular, central nervous system acting and antiviral agents. Therefore, in order to provide optimal drug dosage regimens both in male and female, gender differences in pharmacokinetics, pharmacodynamics, and adverse drug reactions must be considered.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
/ / Health Canada's Gender-based Analysis Policy
Austin KL / 1980 / Intersubject and dose related variability after intravenous administration of erythromycin / Br J Clin Pharmacol 10 : 273 ~ 279
Brinkman-Van der Linden CM / 1996 / Oral estrogen treatment induces a decrease in expression of sialyl Lewis x on alpha 1-acid glycoprotein in females and male-to-female tra
Cummins CL / 2002 / Sex-related differences in the clearance of cytochrome P450 3A4 substrates may be caused by P-glycoprotein / Clin Pharmacol Ther 72 : 474 ~ 489
Dilger K / 1999 / Chronopharmacology of intravenous and oral modified release verapamil / Br J Clin Pharmacol 47 : 413 ~ 419
Austin KL / 1980 / Intersubject and dose related variability after intravenous administration of erythromycin / Br J Clin Pharmacol 10 : 273 ~ 279
Brinkman-Van der Linden CM / 1996 / Oral estrogen treatment induces a decrease in expression of sialyl Lewis x on alpha 1-acid glycoprotein in females and male-to-female tra
Cummins CL / 2002 / Sex-related differences in the clearance of cytochrome P450 3A4 substrates may be caused by P-glycoprotein / Clin Pharmacol Ther 72 : 474 ~ 489
Dilger K / 1999 / Chronopharmacology of intravenous and oral modified release verapamil / Br J Clin Pharmacol 47 : 413 ~ 419
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