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This study was conducted to analyze cost-effectiveness of neoadjuvant chemotherapy for locally advanced head and neck cancer in Korean healthcare setting. We constructed a decision analytical model to estimate total costs and outcomes of paclitaxel+cisplatin (PC) or docetaxel+cisplatin+5-FU (DCF) for 2 years time horizon in 100 patient cohort with locally advanced head and neck cancer. Base analysis showed that cost savings of PC regimen were 379 million Korean Won and 231 million Korean Won in societal and payer's perspectives, respectively, compared to DCF regimen,and life saved was 0.18. PC regimen as a dominant strategy was found to be robust through sensitivity analyses.
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참고문헌 (25)
참고문헌 신청
Adelstein DJ / 2006 / Does Induction Chemotherapy Have a Role in the Management of Locoregionally Advanced Squamous Cell Head and Neck Cancer / J Clin Onco 24 : 2624 ~ 2628
Bristol-Myers Squibb Company / 2007 / A Phase 2 Trial of Neoadjuvant Paclitaxel and Cisplatin in Patients with Locally Advanced Head and Neck Cancer
Cho E / 2005 / Docetaxel and Cisplatin as Induction Chemotherapy in Locally Advanced Head and Neck Cancer / 대한두경부종양학회지 21 (2) : 126 ~ 131
Cho EK / 1996 / Combination Chemotherapy with 5-Fluorouracil and Carboplatin for Advanced Head and Neck Cancer / Joural of Korean Cancer Association 28 (1) : 95 ~ 103
Dunphy FR / 2001 / Induction paclitaxel and carboplatin for patients with head and neck carcinoma / Cancer 91 : 940 ~ 948
Bristol-Myers Squibb Company / 2007 / A Phase 2 Trial of Neoadjuvant Paclitaxel and Cisplatin in Patients with Locally Advanced Head and Neck Cancer
Cho E / 2005 / Docetaxel and Cisplatin as Induction Chemotherapy in Locally Advanced Head and Neck Cancer / 대한두경부종양학회지 21 (2) : 126 ~ 131
Cho EK / 1996 / Combination Chemotherapy with 5-Fluorouracil and Carboplatin for Advanced Head and Neck Cancer / Joural of Korean Cancer Association 28 (1) : 95 ~ 103
Dunphy FR / 2001 / Induction paclitaxel and carboplatin for patients with head and neck carcinoma / Cancer 91 : 940 ~ 948
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