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논문 기본 정보

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학술저널
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한국임상약학회 한국임상약학회지 한국임상약학회지 제27권 제1호
발행연도
2017.1
수록면
22 - 29 (8page)

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Objective: Infection is very common in the elderly, so there is a high prevalence of antibiotics use among this population. Especially, due to the emergence of resistant bacteria, the use of vancomycin is growing. The purpose of this study was to evaluate risk factors associated with vancomycin-induced nephrotoxicity in elderly patients. Methods: The subjects of this study were patients over 18 years old who received intravenous vancomycin in a general hospital located in Gangneung-si, Korea between August 1, 2013 and July 31, 2015. Data collection regarding vancomycin use and baseline characteristics was conducted using computerized hospital database. Logistic regression analysis was used to identify risk factors associated with vancomycin-induced nephrotoxicity. Results: A total of 290 patients were finally included, and 191(66%) out of these patients were age 65 or older. The incidence of vancomycin-induced nephrotoxicity was 11.0%, 12.6%, and 7.0% in the all adult patients, the elderly patients, and the non-elderly patients, respectively. There were significant differences in comorbidities between patients with nephrotoxicity and patients without nephrotoxicity in the all adult patients, and there were significant differences in vancomycin duration, comorbidities, and number of nephrotoxic agents between patients with nephrotoxicity and patients without nephrotoxicity in the elderly patients. However, according to the logistic regression analysis, there was no significant risk factor that increases the incidence ofvancomycin-induced nephrotoxicity in all three age groups. Conclusion: There were no differences in risk factors that increase the incidence of vancomycin-induced nephrotoxicity between all adult patients, elderly patients, and non-elderly patients. Further studies with larger sample sizes to identify risk factors associated with vancomycin-induced nephrotoxicity in the elderly to improve the outcome of pharmacotherapy are required.
#Risk factors #acute kidney injury #vancomycin #nephrotoxicity #elderly

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참고문헌 (23)

참고문헌 신청
Beard Jr EL / 2001 / The American Society of Health System Pharmacists / JONAS Healthc Law Ethics Regul 3 (3) : 78 ~ 79 google schola Beeson P / 1985 / Alleged susceptibility of the elderly to infection / Yale J Biol Med 58 (2) : 71 ~ google schola Berg RL / 1990 / The second fifty years: Promoting health and preventing disability / National Academy Press google schola Cano EL / 2012 / Incidence of nephrotoxicity and association with vancomycin use in intensive care unit patients with pneumonia : retrospective analysis of the IMPACT-HAP Da google schola Elyasi S / 2012 / Vancomycin-induced nephrotoxicity: mechanism, incidence, risk factors and special populations. A literature review / Eur J Clin Pharmacol 68 (9) : 1243 ~ 1 google schola

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