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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Etoposide (Eto) is chemotherapeutic compounds that is currently used in the treatment of metastatic prostate cancer but
new therapeutic agents are needed for the treatment of androgen-independent prostate cancer. The objective of the present
study was to determine whether vitamin C (VC), the antioxidant, plays a role in regulating the growth of prostate
cancer cell lines and whether VC has synergistic effect to tumor cell killing by chemotherapeutic drugs. Androgendependent
LNCaP and androgen-independent DU-145 prostate cancer cell lines were used in this study. Both cells
presented increase of dose- and time-dependent cytotoxicity in Eto-treated cultures. The combined treatment with Eto and
VC significantly increased the percentage of apoptotic cells compared to Eto-treated cells (p⁄0.05). The present findings
demonstrated that VC inhibited the growth of prostate cancer cell lines by Eto-mediated cytotoxicity and induced
apoptosis. These results suggest that the chemotherapeutic effect of Eto on prostate cancer can be enhanced by VC.
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참고문헌 (24)
참고문헌 신청
Berruti A / 2005 / Oral estramustine plus oral etoposide in the treatment of hormone refractory prostate cancer patients: a phase II study with a 5 year follow-up / Urol Onco
Borner MM / 1995 / Drug induced apoptosis is not necessarily dependent on macromolecular synthesis of proliferation in the p53 negative human prostate cancer cell line PC-3 /
Diaz M / 2004 / Management of androgen-independent prostate cancer / Cancer Control 11 : 364 ~ 373
Eastman A / 1990 / Activation of programmed cell death by anticancer agents: cisplatin as a model system / Cancer Cells (Cold Spring Harbor 2 : 275 ~ 280
English HF / 1989 / Relationship between DNA fragmentation and apoptosis in the programmed cell death in the rat prostate following castration / Prostate 15 : 233 ~ 250
Borner MM / 1995 / Drug induced apoptosis is not necessarily dependent on macromolecular synthesis of proliferation in the p53 negative human prostate cancer cell line PC-3 /
Diaz M / 2004 / Management of androgen-independent prostate cancer / Cancer Control 11 : 364 ~ 373
Eastman A / 1990 / Activation of programmed cell death by anticancer agents: cisplatin as a model system / Cancer Cells (Cold Spring Harbor 2 : 275 ~ 280
English HF / 1989 / Relationship between DNA fragmentation and apoptosis in the programmed cell death in the rat prostate following castration / Prostate 15 : 233 ~ 250
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