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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
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- 1 - 9 (9page)
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Background: Peroxisome proliferator-activated receptor gamma (PPARG), CCAAT/enhancer binding protein alpha (CEBPA) and retinoid X receptor alpha (RXRA) are nuclear transcription factors that play important roles in regulation of adipogenesis and fat deposition. The objectives of this study were to characterise the variability of these three candidate genes in a mixed sample panel composed of several cattle breeds with different meat quality, validate single nucleotide polymorphisms (SNPs) in a local crossbred population (Angus - Hereford - Limousin) and evaluate their effects on meat quality traits (backfat thickness, intramuscular fat content and fatty acid composition), supporting the association tests with bioinformatic predictive studies.
Results: Globally, nine SNPs were detected in the PPARG and CEBPA genes within our mixed panel, including a novel SNP in the latter. Three of these nine, along with seven other SNPs selected from the Single Nucleotide Polymorphism database (SNPdb), including SNPs in the RXRA gene, were validated in the crossbred population (N = 260). After validation, five of these SNPs were evaluated for genotype effects on fatty acid content and composition. Significant effects were observed on backfat thickness and different fatty acid contents (P < 0.05). Some of these SNPs caused slight differences in mRNA structure stability and/or putative binding sites for proteins.
Conclusions: PPARG and CEBPA showed low to moderate variability in our sample panel. Variations in these genes, along with RXRA, may explain part of the genetic variation in fat content and composition. Our results may contribute to knowledge about genetic variation in meat quality traits in cattle and should be evaluated in larger independent populations.
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참고문헌 (26)
참고문헌 신청
Shahidi F / 2002 / Meat processing: improving meat quality / Woodhead Publishing Limited :105~121
Du M / 2010 / Cellular signaling pathways regulating the initial stage of adipogenesis and marbling of skeletal muscle / Meat Sci 86(1):103~109
Hausman GJ / 2009 / Board-invited review: the biology and regulation of preadipocytes and adipocytes in meat animals / J Anim Sci 87(4):1218~1246
William Barendse / 2011 / Haplotype Analysis Improved Evidence for Candidate Genes for Intramuscular Fat Percentage from a Genome Wide Association Study of Cattle / PLoS ONE 6(12):e29601
Fan YY / 2011 / Three novel SNPs in the coding region of PPARγ gene and their associations with meat quality traits in cattle / Mol Biol Rep 38(1):131~137
Du M / 2010 / Cellular signaling pathways regulating the initial stage of adipogenesis and marbling of skeletal muscle / Meat Sci 86(1):103~109
Hausman GJ / 2009 / Board-invited review: the biology and regulation of preadipocytes and adipocytes in meat animals / J Anim Sci 87(4):1218~1246
William Barendse / 2011 / Haplotype Analysis Improved Evidence for Candidate Genes for Intramuscular Fat Percentage from a Genome Wide Association Study of Cattle / PLoS ONE 6(12):e29601
Fan YY / 2011 / Three novel SNPs in the coding region of PPARγ gene and their associations with meat quality traits in cattle / Mol Biol Rep 38(1):131~137
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