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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 1 - 7 (7page)
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A well-characterized sperm specific protein of the Member of immunoglobulin superfamily, IZUMO1, has crucial role in fertilization by mediating sperm binding to the egg plasma membrane in the mouse. However little is known about IZUMO1 in bovine. Here, we describe the molecular cloning and expression analysis of bovine IZUMO1 (bIZUMO1). RT-PCR and Western blot analysis of the bovine tissues indicated that bIZUMO1 was specifically expressed in the testis and sperm, Furthermore, the result of our biotinylation assay from ejaculated bovine sperm strongly suggest the assumption that bIZUMO1 is localized on the cell surface. These data imply the potential role of bovine IZUMO1 in mammalian fertilization.
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참고문헌 (16)
참고문헌 신청
Bazzoni G / 2003 / The JAM family of junctional adhesion molecules / Curr Opin Cell Biol 15 : 525 ~ 530
Cherr GN / 2001 / The dual functions of GPI-anchored PH-20 : hyaluronidase and intracellular signaling / Matrix Biol 20 : 515 ~ 525
Clark S / 2013 / Presence and incidence of izumo antibodies in sera of immunoinfertile women and men / Am J Reprod Immunol 69 : 256 ~ 263
Ellerman DA / 2009 / Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm / Mol Reprod Dev 76 : 1188 ~ 1199
Inoue N / 2005 / The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs / Nature 434 : 234 ~ 238
Cherr GN / 2001 / The dual functions of GPI-anchored PH-20 : hyaluronidase and intracellular signaling / Matrix Biol 20 : 515 ~ 525
Clark S / 2013 / Presence and incidence of izumo antibodies in sera of immunoinfertile women and men / Am J Reprod Immunol 69 : 256 ~ 263
Ellerman DA / 2009 / Izumo is part of a multiprotein family whose members form large complexes on mammalian sperm / Mol Reprod Dev 76 : 1188 ~ 1199
Inoue N / 2005 / The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs / Nature 434 : 234 ~ 238
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