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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 201 - 208 (8page)
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초록· 키워드
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Background and Purpose An increase in brain water diffusivity as measured using magnetic resonance imaging (MRI) has been recently reported in normal-appearing white matter (NAWM) in patients affected by cognitive impairment. However, it remains to be clarified if this reflects an overt neuronal tissue disruption that leads to degenerative or microvascular lesions. This question was addressed by comparing the regional MRI apparent diffusion coefficients (ADCs) of NAWM in patients affected by Alzheimer’s disease (AD) or vascular dementia (VaD). The relationships of ADCs with the white-matter hyperintensity (WMH) burden, carotid atherosclerosis, and cognitive performance were also investigated.
Methods Forty-nine AD and 31 VaD patients underwent brain MRI to assess the WMH volume and regional NAWM ADCs, neuropsychological evaluations, and carotid ultrasound to assess the plaque severity and intima-media thickness (IMT).
Results Regional ADCs in NAWM did not differ between VaD and AD patients, while the WMH volume was greater in VaD than in AD patients. The ADC in the anterior corpus callosum was related to the WMH volume, while a greater carotid IMT was positively correlated with the temporal ADC and WMH volume. The memory performance was worse in patients with higher temporal ADCs. Constructional praxis scores were related to ADCs in the frontal, and occipital lobes, in the anterior and posterior corpus callosum as well as to the WMH volume. Abstract reasoning was related to frontal, parietal, and temporal ADCs.
Conclusions Our data show that higher regional ADCs in NAWM are associated with microcirculatory impairment, as depicted by the WMH volume. Moreover, regional ADCs in NAWM are differently associated with the neuropsychological performances in memory, constructional praxia, and abstract reasoning domains.
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참고문헌 (46)
참고문헌 신청
Viticchi G / 2012 / Vascular predictors of cognitive decline in patients with mild cognitive impairment / Neurobiol Aging 33:1127.e1~1127.e9
Iadecola C / 2010 / The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia / Acta Neuropathol 120:287~296
van Oijen M / 2007 / Atherosclerosis and risk for dementia / Ann Neurol 61:403~410
Altamura C / 2007 / What is the relationship among atherosclerosis markers, apolipoprotein E polymorphism and dementia? / Eur J Neurol 14:679~682
de la Torre JC / 2010 / The vascular hypothesis of Alzheimer’s disease: bench to bedside and beyond / Neurodegener Dis 7:116~121
Iadecola C / 2010 / The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia / Acta Neuropathol 120:287~296
van Oijen M / 2007 / Atherosclerosis and risk for dementia / Ann Neurol 61:403~410
Altamura C / 2007 / What is the relationship among atherosclerosis markers, apolipoprotein E polymorphism and dementia? / Eur J Neurol 14:679~682
de la Torre JC / 2010 / The vascular hypothesis of Alzheimer’s disease: bench to bedside and beyond / Neurodegener Dis 7:116~121
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