지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Purpose: To develop a new diffusion-based functional MRI (fMRI) sequence to generate apparent diffusion coefficient (ADC) maps in single excitation and evaluate the contribution of b0 signal on neuronal changes. Materials and Methods: A diffusion-based fMRI sequence was d esigned with single measurement that can acquire images of three directions at a time, obtaining b = 0 s/mm2 during the first baseline condition (b0_b), followed by 107 diffusion-weighted imaging (DWI) with b = 600 s/mm2 during the b aseline and visual stimulation conditions, and another b = 0 s/mm2 during the last activation condition (b0_a). ADC was mapped in three different ways: 1) using b0_b (ADC_b) for all time points, 2) using b0_a (ADC_a) for all time points, and 3) using b0_b and b0_a (ADC_ba) for baseline and stimulation scans, respectively. The fMRI studies were conducted on the brains of 16 young healthy volunteers using visual stimulations in a 3T MRI system. In addition, the blood oxygen level dependent (BOLD) fMRI was also acquired to compare it with diffusion-based fMRI. A sample t-test was used to investigate the voxel-wise average between the subjects. Results: The BOLD data consisted of only activated voxels. However, ADC_ba data was observed in both deactivated and activated voxels. There were no statistically significant activated or deactivated voxels for DWI, ADC_b, and ADC_a. Conclusions: With the new sequence, neuronal activations can be mapped with visual stimulation as compared to the baseline condition in several areas in the brain. We showed that ADC should be mapped using both DWI and b0 images acquired with the same conditions.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Darquie A / 2001 / Transient decrease in water diffusion observed in human occipital cortex during visual stimulation [published online ahead of print 2001/07/19] / Proc Natl Acad Sci U S A 98(16):9391~9395
Roy CS / 1890 / On the Regulation of the Bloodsupply of the Brain [published online ahead of print 1890/01/01] / J Physiol 11(1-2):85~158
Bandettini PA / 1992 / Time course EPI of human brain function during task activation [published online ahead of print 1992/06/01] / Magn Reson Med 25(2):390~397
Kwong KK / 1992 / Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation [published online ahead of print 1992/06/15] / Proc Natl Acad Sci U S A 89(12):5675~5679
Ogawa S / 1992 / Intrinsic signal changes accompanying sensory stimulation : functional brain mapping with magnetic resonance imaging [published online ahead of print 1992/07/01] / Proc Natl Acad Sci U S A 89(13):5951~5955
Roy CS / 1890 / On the Regulation of the Bloodsupply of the Brain [published online ahead of print 1890/01/01] / J Physiol 11(1-2):85~158
Bandettini PA / 1992 / Time course EPI of human brain function during task activation [published online ahead of print 1992/06/01] / Magn Reson Med 25(2):390~397
Kwong KK / 1992 / Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation [published online ahead of print 1992/06/15] / Proc Natl Acad Sci U S A 89(12):5675~5679
Ogawa S / 1992 / Intrinsic signal changes accompanying sensory stimulation : functional brain mapping with magnetic resonance imaging [published online ahead of print 1992/07/01] / Proc Natl Acad Sci U S A 89(13):5951~5955
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