지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.10
- 수록면
- 371 - 387 (17page)
이용수
초록· 키워드
오류제보하기
Although the dried root of Saposhnikovia divaricata (Turcz.) Schischk. (Umbelliferae) is a popular medicinal plant in East Asia, there has been no systemic toxicological evaluation of a water extract of Saposhnikoviae Radix (SRE). In this experiment, an oral acute and 13-week subchronic toxicological evaluations of SRE (500-5,000 ㎎/㎏ body weight) were performed in both sexes of Crl:CD(SD) rats. Based on the results from mortality, clinical signs, effects on body weight and organ weight, clinical biochemistry, hematology, urinalysis, and histopathology, significant acute, 4-week repeated dose range finding (DRF) and 13-week subchronic toxicity of SRE was not observed in either sex of rats; thus, the no observed adverse effect level (NOAEL) was 5,000 mg (kg/day). To identify anti-hyperuricemia potential of SRE, the suppressive effect of SRE was determined in mice challenged with potassium oxonate (PO; 250 ㎎/㎏) via intraperitoneal injection for 8 days (each group; n = 7). SRE supplementation suppressed the uric acid level in urine through significant xanthine oxidase (XO) inhibitory activity. Kidney dysfunctions were observed in PO-challenged mice as evidenced by an increase in serum creatinine level. Whereas, SRE supplementation suppressed it in a dose-dependent manner. Collectively, SRE was safe up to 5,000 ㎎ (㎏/day) based on NOAEL found from acute and 13-week subchronic toxicological evaluations. SRE had anti-hyperuricemia effect and lowered the excessive level of uric acid, a potential factor for gout and kidney failure.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (36)
참고문헌 신청
WHO / 2013 / WHO traditional medicine strategy: 2014-2023
Fan, T. P. / 2012 / Future development of global regulations of Chinese herbal products / J. Ethnopharmacol 140:568~586
Kreiner, J. / 2017 / Saposhnikoviae divaricata: a phytochemical, pharmacological, and pharmacokinetic review / Chin. J. Nat. Med 15:255~264
Liu, R. / 2008 / Separation and purification of four chromones from radix saposhnikoviae by highspeed counter-current chromatography / Phytochem. Anal 19:206~211
Wang, C. N. / 2000 / Inducible nitric oxide synthase inhibitors from Saposhnikovia divaricata and Panax quinquefolium / Planta Med 66:644~647
Fan, T. P. / 2012 / Future development of global regulations of Chinese herbal products / J. Ethnopharmacol 140:568~586
Kreiner, J. / 2017 / Saposhnikoviae divaricata: a phytochemical, pharmacological, and pharmacokinetic review / Chin. J. Nat. Med 15:255~264
Liu, R. / 2008 / Separation and purification of four chromones from radix saposhnikoviae by highspeed counter-current chromatography / Phytochem. Anal 19:206~211
Wang, C. N. / 2000 / Inducible nitric oxide synthase inhibitors from Saposhnikovia divaricata and Panax quinquefolium / Planta Med 66:644~647
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