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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 247 - 260 (14page)
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초록· 키워드
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Objective. Elevated uric acid is associated with cardiovascular disease and metabolic syndrome. However, uric acid is also an antioxidant with beneficial effect on comorbidities. The aim of this study was to evaluate the relationship of serum uric acid with diabetes, metabolic syndrome, and cardiovascular disease in a Korean adult population. Methods. A total of 5,887 (weighted n=40,251,868) participants aged ≥19 years from the 2016 Korean National Health and Nutrition Examination Survey were included for analysis. Weighted prevalence and odds ratio (OR) of comorbidities were analyzed according to the presence of hyperuricemia and uric acid quartile. Results. Participants of both sexes with hyperuricemia showed higher prevalence of metabolic syndrome, hypertension, hypertriglyceridemia, and obesity than those without hyperuricemia. After adjusting for socioeconomic and lifestyle characteristics, hyperuricemia was associated with a decreased prevalence of diabetes mellitus in men (OR: 0.44, 95% confidence interval [CI]: 0.28∼0.72, p=0.001) and a decreased prevalence of myocardial infarction or angina (OR: 0.25, 95% CI: 0.08∼0.75, p=0.013) in women. Hyperuricemia was significantly associated with an increased prevalence of metabolic syndrome in both men (OR: 1.81, 95% CI: 1.33∼2.45, p＜0.001) and women (OR: 1.95, 95% CI: 1.22∼ 3.13, p=0.006). Conclusion. Hyperuricemia was associated with a decreased prevalence of diabetes mellitus in men and a decreased prevalence of myocardial infarction or angina in women. Hyperuricemia was associated with an increased prevalence of metabolic syndrome in both men and women.
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참고문헌 (30)
참고문헌 신청
Iso T / 2015 / Extremely low levels of serum uric acid are associated with endothelial dysfunction in humans / Circ J 79:978~980
Waring WS / 2006 / Uric acid restores endothelial function in patients with type 1 diabetes and regular smokers / Diabetes 55:3127~3132
Bandaru P / 2011 / Association between serum uric acid levels and diabetes mellitus / Int J Endocrinol 2011:604715
Oda E / 2009 / Uric acid is positively associated with metabolic syndrome but negatively associated with diabetes in Japanese men / Intern Med 48:1785~1791
Barbieri L / 2015 / Impact of sex on uric acid levels and its relationship with the extent of coronary artery disease : a single-centre study / Atherosclerosis 241:241~248
Waring WS / 2006 / Uric acid restores endothelial function in patients with type 1 diabetes and regular smokers / Diabetes 55:3127~3132
Bandaru P / 2011 / Association between serum uric acid levels and diabetes mellitus / Int J Endocrinol 2011:604715
Oda E / 2009 / Uric acid is positively associated with metabolic syndrome but negatively associated with diabetes in Japanese men / Intern Med 48:1785~1791
Barbieri L / 2015 / Impact of sex on uric acid levels and its relationship with the extent of coronary artery disease : a single-centre study / Atherosclerosis 241:241~248
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