지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 373 - 379 (7page)
이용수
초록· 키워드
오류제보하기
Background/Aims: Recurrent pyogenic cholangitis (RPC) is a chronic progressive disease frequently accompanied by cholangiocarcinoma (CCA). This study aimed to investigate the natural course of RPC and identify factors associated with CCA. Methods: From January 2005 to December 2016, 310 patients diagnosed with RPC at Seoul National University Hospital were included. Complications and management during follow-up were recorded. CCA-free probability was estimated by Kaplan-Meier method, and risk factors associated with CCA were analyzed using log-rank test and Cox’s proportional hazard regression model. Results: Mean age at diagnosis was 59.1±10.9 years and mean follow-up duration was 84.0±64.1 months. An intrahepatic duct stone was found in 253 patients (81.6%). Liver atrophy was identified in 185 patients (59.7%) and most commonly located at the left lobe (65.4%). Acute cholangitis, liver abscesses, cirrhotic complications, and CCA developed in 41.3%, 19.4%, 9.7%, and 7.4%, respectively. During follow-up, complete resolution rate after hepatectomy, biliary bypass surgery, and choledocholithotomy with T-tube insertion reached 82.3%, 55.2%, and 42.1%, respectively. None of the patients who maintained complete resolution by the last follow-up day developed CCA. In univariate analysis, female, both-sided intrahepatic duct stones, and liver atrophy at any location were associated with increased risk of CCA. Multivariate analysis revealed that both-sided atrophy significantly increased risk of CCA (hazard ratio, 4.56; 95% confidence interval, 1.48 to 14.09; p=0.008). In 21 patients who developed intrahepatic CCA, tumor was located mostly in the atrophied lobe (p=0.023). Conclusions: In RPC patients, acute cholangitis, liver abscess, cirrhotic complications, and CCA frequently developed. Both-sided liver atrophy was a significant risk factor for developing CCA.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Digby KH / 1930 / Common-duct stone of liver origin / Br J Surg 17:578~591
Cook J / 1954 / Recurrent pyogenic cholangeitis / Br J Surg 42:188~203
Tsui WM / 2011 / Primary hepatolithiasis, recurrent pyogenic cholangitis, and oriental cholangiohepatitis : a tale of 3 countries / Adv Anat Pathol 18:318~328
Lee KF / 2009 / Outcome of surgical treatment for recurrent pyogenic cholangitis: a single-centre study / HPB(Oxford) 11:75~80
Kwan KE / 2017 / Recurrent pyogenic cholangitis: a review of imaging findings and clinical management / Abdom Radiol(NY) 42:46~56
Cook J / 1954 / Recurrent pyogenic cholangeitis / Br J Surg 42:188~203
Tsui WM / 2011 / Primary hepatolithiasis, recurrent pyogenic cholangitis, and oriental cholangiohepatitis : a tale of 3 countries / Adv Anat Pathol 18:318~328
Lee KF / 2009 / Outcome of surgical treatment for recurrent pyogenic cholangitis: a single-centre study / HPB(Oxford) 11:75~80
Kwan KE / 2017 / Recurrent pyogenic cholangitis: a review of imaging findings and clinical management / Abdom Radiol(NY) 42:46~56
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Evaluation of Cholangiocarcinoma Risk and its Related Factors In Wetland Geographical Communities of Ubon Ratchathani, Thailand
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Surveillance of Populations at Risk of Cholangiocarcinoma Development in Rural Communities of Thailand Using the Korat-CCA Verbal Screening Test
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Cholangiocarcinoma: Current Knowledge and New Developments
Gut and Liver
2017 .01
-
Current Insights on Cholangiocarcinoma Research: a Brief Review
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Community Participation in Cholangiocarcinoma Prevention in Ubon Ratchathani, Thailand: Relations with Age and Health Behavior
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Helicobacter Species are Possible Risk Factors of Cholangiocarcinoma
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Effect of Combining EGFR Tyrosine Kinase Inhibitors and Cytotoxic Agents on Cholangiocarcinoma Cells
Cancer Research and Treatment
2021 .01
-
Cholangiocarcinoma: Consensus statement from ENS-CCA
Annals of Hepato-Biliary-Pancreatic Surgery
2021 .12
-
Benefits of Metformin Use for Cholangiocarcinoma
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
뇌경색 환자의 경동맥 내막 두께와 가속도맥파 검사의 관련성 연구
동의생리병리학회지
2015 .04
-
뇌경색 환자의 경동맥 내막 두께와 사속도맥파 검사의 관련성 연구
동의생리병리학회지
2015 .01
-
Utilization of Google Earth for Distribution Mapping of Cholangiocarcinoma: a Case Study in Satuek District, Buriram, Thailand
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Liver Fluke-Associated Biliary Tract Cancer
Gut and Liver
2018 .01
-
Update on the risk factors for opisthorchiasis and cholangiocarcinoma in Thailand
Parasites, Hosts and Diseases
2023 .11
-
Relationship between Clonorchis sinensis Infection and Cholangiocarcinoma in Korea
Parasites, Hosts and Diseases
2022 .08
-
GIS Database and Google Map of the Population at Risk of Cholangiocarcinoma in Mueang Yang District, Nakhon Ratchasima Province of Thailand
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Spatial Distribution of the Population at Risk of Cholangiocarcinoma in Chum Phaung District, Nakhon Ratchasima Province of Thailand
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
The effect and therapeutic compliance of adjuvant therapy in patients with cholangiocarcinoma after R0 resection: a retrospective study
Journal of Yeungnam Medical Science
2023 .01
-
Diagnosis and Treatment of Perihilar Cholangiocarcinoma: A National Survey from the Korean Pancreatobiliary Association
Gut and Liver
2024 .01
-
Quantitative Changes in Tumor-Associated M2 Macrophages Characterize Cholangiocarcinoma and their Association with Metastasis
Asian Pacific journal of cancer prevention : APJCP
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0