지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 471 - 478 (8page)
이용수
초록· 키워드
오류제보하기
Background/Aims: Metallic stents designed to relieve malignant biliary obstruction are susceptible to occlusive tumor ingrowth or overgrowth. In a previous report, we described metallic stents covered with paclitaxel-incorporated membrane (MSCPM-I, II) to prevent occlusion from tumor ingrowth via antitumor effect. This new generation paclitaxeleluting biliary stent is further endowed with sodium caprate (MSCPM-III) for enhanced drug delivery. The purpose of this study is to examine the safety of its drug delivery system in the porcine biliary tract. Methods: MSCPM-III (10% [wt/vol] paclitaxel) and covered metal stents (CMSs) were endoscopically inserted in porcine bile ducts in vivo. Histologic biliary changes, levels of paclitaxel released, and various serum analytes (albumin, alkaline phosphate, aspartate transaminase, alanine transaminase, total protein, total bilirubin, and direct bilirubin) were assessed. Results: Based on the intensity of reactive inflammation and fibrosis, changes in porcine biliary epithelium secondary to implanted MSCPMIII were deemed acceptable (i.e., safe). Histologic features in the MSCPM-III and CMS groups did not differ significantly. In a related serum analysis, paclitaxel release from MSCPMIII stents was below the limit of detection for 28 days. Biochemical analyses were also similar for the two groups, and no evidence of hepatic or renal toxicity was found in animals receiving MSCPM-III stents. Conclusions: In a prototypic porcine trial, this newly devised metal biliary stent incorporating both paclitaxel and sodium caprate appears to be safe in the porcine bile duct.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Andersen JR / 1989 / Randomised trial of endoscopic endoprosthesis versus operative bypass in malignant obstructive jaundice / Gut 30:1132~1135
Wagner HJ / 1993 / Plastic endoprostheses versus metal stents in the palliative treatment of malignant hilar biliary obstruction. A prospective and randomized trial / Endoscopy 25:213~218
Yoon WJ / 2006 / A comparison of covered and uncovered Wallstents for the management of distal malignant biliary obstruction / Gastrointest Endosc 63:996~1000
Telford JJ / 2010 / A randomized trial comparing uncovered and partially covered self-expandable metal stents in the palliation of distal malignant biliary obstruction / Gastrointest Endosc 72:907~914
Lee DK / 2005 / The effect on porcine bile duct of a metallic stent covered with a paclitaxel-incorporated membrane / Gastrointest Endosc 61:296~301
Wagner HJ / 1993 / Plastic endoprostheses versus metal stents in the palliative treatment of malignant hilar biliary obstruction. A prospective and randomized trial / Endoscopy 25:213~218
Yoon WJ / 2006 / A comparison of covered and uncovered Wallstents for the management of distal malignant biliary obstruction / Gastrointest Endosc 63:996~1000
Telford JJ / 2010 / A randomized trial comparing uncovered and partially covered self-expandable metal stents in the palliation of distal malignant biliary obstruction / Gastrointest Endosc 72:907~914
Lee DK / 2005 / The effect on porcine bile duct of a metallic stent covered with a paclitaxel-incorporated membrane / Gastrointest Endosc 61:296~301
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Efficacy of a Multiplex Paclitaxel Emission Stent Using a Pluronic® Mixture Membrane versus a Covered Metal Stent in Malignant Biliary Obstruction: A Prospective Randomized Comparative Study
Gut and Liver
2017 .07
-
약물 방출 담도 스텐트
대한췌담도학회지
2020 .01
-
Current Status of Biliary Metal Stents
Clinical Endoscopy
2016 .01
-
Usefulness of stent placement above the papilla, so-called, ‘inside stent’
International Journal of Gastrointestinal Intervention
2018 .01
-
TOKYO criteria: Standardized reporting system for endoscopic biliary stent placement
International Journal of Gastrointestinal Intervention
2018 .01
-
A Double-Layered Covered Biliary Metal Stent for the Management of Unresectable Malignant Biliary Obstruction: A Multicenter Feasibility Study
Gut and Liver
2016 .01
-
Development of Biliary and Enteral Stents by the Korean Gastrointestinal Endoscopists
Clinical Endoscopy
2016 .01
-
Basic Knowledge about Metal Stent Development
Clinical Endoscopy
2016 .01
-
Mechanisms of Biliary Plastic Stent Occlusion and Efforts at Prevention
Clinical Endoscopy
2016 .01
-
Preventive effect of biodegradable stents on biliary stricture and fibrosis after biliary anastomosis in a porcine model
Annals of Surgical Treatment and Research
2022 .02
-
Is There Room for Improvement in Increasing the Stent Patency of Biliary Plastic Stents?
Gut and Liver
2016 .01
-
Strategies to Overcome Risks Associated with Endoscopic Biliary Stenting
Clinical Endoscopy
2019 .01
-
Antireflux Metal Stent as a First-Line Metal Stent for Distal Malignant Biliary Obstruction: A Pilot Study
Gut and Liver
2017 .01
-
Complex percutaneous biliary procedures: Review and contributions of a high volume team
International Journal of Gastrointestinal Intervention
2019 .01
-
Indwelling of External Biliary Stent
대한외과학회 학술대회 초록집
2020 .11
-
Stepwise Algorithmic Approach to Endoscopic Removal of Biliary Partially Covered and Uncovered Self-Expanding Metal Stents
Clinical Endoscopy
2021 .01
-
Prospective Multicenter Study of the Challenges Inherent in Using Large Cell-Type Stents for Bilateral Stent-in-Stent Placement in Patients with Inoperable Malignant Hilar Biliary Obstruction
Gut and Liver
2018 .01
-
Comparison of Outcomes between 7-French and 10-French Plastic Stents for Patients with Biliary Tract Cancer
대한췌담도학회지
2017 .01
-
Endoscopic Management of Anastomotic Strictures after Liver Transplantation
Clinical Endoscopy
2016 .01
-
Proximal Stent Migration of Fully Covered Self-Expandable Metal Stent following Side-by-Side Deployment in the Patient with Klatskin Tumor: A Case Report
대한췌담도학회지
2024 .07
이 논문의 저자 정보
최근 본 자료
댓글(0)
0