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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 567 - 573 (7page)
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초록· 키워드
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Background/Aims: A drug-eluting stent for unresectable malignant biliary obstruction was developed to increase stent patency by preventing tumor ingrowth. The safety and efficacy of a new generation of metallic stents covered with a paclitaxel-incorporated membrane using a Pluronic® mixture (MSCPM-II) were compared prospectively with those of covered metal stents (CMSs) in patients with malignant biliary obstructions. Methods: This study was initially designed as a prospective randomized trial but was closed early because of a high incidence of early occlusion. Therefore, the data were analyzed using the intent-to-treat method. A total of 72 patients with unresectable distal malignant biliary obstructions were prospectively enrolled. Results: The two groups did not differ significantly in basic characteristics and mean followup period (MSCPM-II 194 days vs CMS 277 days, p=0.063).
Stent occlusion occurred in 14 patients (35%) who received MSCPM-II and in seven patients (21.9%) who received CMSs.
Stent patency and survival time did not significantly differ between the two groups (p=0.355 and p=0.570). The complications were mild and resolved by conservative management in both groups. Conclusions: There were no significant differences in stent patency or patient survival in MSCPM-II and CMS patients with malignant biliary obstructions.
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등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Smith AC / 1994 / Randomised trial of endoscopic stenting versus surgical bypass in malignant low bileduct obstruction / Lancet 344:1655~1660
Andersen JR / 1989 / Randomised trial of endoscopic endoprosthesis versus operative bypass in malignant obstructive jaundice / Gut 30:1132~1135
Larssen L / 2012 / Long-term outcome of palliative treatment with self-expanding metal stents for malignant obstructions of the GI tract / Scand J Gastroenterol 47:1505~1514
Wagner HJ / 1993 / Plastic endoprostheses versus metal stents in the palliative treatment of malignant hilar biliary obstruction: a prospective and randomized trial / Endoscopy 25:213~218
O’Brien S / 1995 / A three year follow up of self expanding metal stents in the endoscopic palliation of longterm survivors with malignant biliary obstruction / Gut 36:618~621
Andersen JR / 1989 / Randomised trial of endoscopic endoprosthesis versus operative bypass in malignant obstructive jaundice / Gut 30:1132~1135
Larssen L / 2012 / Long-term outcome of palliative treatment with self-expanding metal stents for malignant obstructions of the GI tract / Scand J Gastroenterol 47:1505~1514
Wagner HJ / 1993 / Plastic endoprostheses versus metal stents in the palliative treatment of malignant hilar biliary obstruction: a prospective and randomized trial / Endoscopy 25:213~218
O’Brien S / 1995 / A three year follow up of self expanding metal stents in the endoscopic palliation of longterm survivors with malignant biliary obstruction / Gut 36:618~621
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