지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives: Inflammation is a major mechanism underlying coronary heart disease (CHD) and C-reactive protein (CRP) is a marker of inflammation. When administered soon after menopause, menopausal hormone therapy (MHT) prevents CHD. This study was conducted to examine the impact of estrogen by administration route on CRP in postmenopausal Korean women using micronized progesterone (MP4) for endometrial protection. Methods: This retrospective cohort study included 129 healthy women without CHD risk factors. Eighty-nine women took oral estrogen (conjugated equine estrogen, 0.625 mg/day or equivalent), and 40 women applied a 1.5-mg/day 0.1% percutaneous estradiol gel. MP4 was added in 82 women with an intact uterus. The CRP level was measured at baseline and three and six months after initiation of MHT. Results: The baseline characteristics were comparable between the MHT groups except current age and age at menopause. After controlling for age, menopausal age, body mass index, and basal CRP, no significant change in CRP was observed in the oral estrogen group (n = 29). Follow-up CRP levels were also similar to the baseline in the percutaneous estrogen group (n = 18). However, three-month CRP was significantly lower than six-month CRP, and there was a significant time trend within the percutaneous estrogen group. However, the group difference did not reach statistical significance. CRP also did not differ by addition of MP4 in either group. Conclusions: In postmenopausal Korean women, no change in CRP was observed with oral estrogen, while percutaneous estrogen might decrease CRP. The estrogenic impacts were not influenced by adding MP4.
목차
등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Ridker PM / 2000 / C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women / N Engl J Med 342:836~843
Ridker PM / 1999 / Hormone replacement therapy and increased plasma concentration of C-reactive protein / Circulation 100:713~716
Haverkate F / 1997 / Production of C-reactive protein and risk of coronary events in stable and unstable angina. European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group / Lancet 349:462~466
Tracy RP / 1997 / Relationship of C-reactive protein to risk of cardiovascular disease in the elderly. Results from the Cardiovascular Health Study and the Rural Health Promotion Project / Arterioscler Thromb Vasc Biol 17:1121~1127
Ridker PM / 1997 / Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men / N Engl J Med 336:973~979
Ridker PM / 1999 / Hormone replacement therapy and increased plasma concentration of C-reactive protein / Circulation 100:713~716
Haverkate F / 1997 / Production of C-reactive protein and risk of coronary events in stable and unstable angina. European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group / Lancet 349:462~466
Tracy RP / 1997 / Relationship of C-reactive protein to risk of cardiovascular disease in the elderly. Results from the Cardiovascular Health Study and the Rural Health Promotion Project / Arterioscler Thromb Vasc Biol 17:1121~1127
Ridker PM / 1997 / Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men / N Engl J Med 336:973~979
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