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논문 기본 정보
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- 저자정보
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제1호
- 발행연도
- 2019.1
- 수록면
- 1 - 10 (10page)
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Gram-negative pathogens, such as Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii, pose a serious threat to public health worldwide, due to high rates of antibiotic resistance and the lack of development of novel antimicrobial agents targeting Gram-negative bacteria. The outer membrane (OM) of Gram-negative bacteria is a unique architecture that acts as a potent permeability barrier against toxic molecules, such as antibiotics. The OM is composed of phospholipids, lipopolysaccharide (LPS), outer membrane β-barrel proteins (OMP), and lipoproteins. These components are synthesized in the cytoplasm or in the inner membrane, and are then selectively transported to the OM by the specific transport machines, including the Lol, BAM, and Lpt pathways. In this review, we summarize recent studies on the assembly systems of OM components and analyze studies for the development of inhibitors that target these systems. These analyses show that OM assembly machines have the potential to be a novel attractive drug target of Gram-negative bacteria.
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참고문헌 (73)
참고문헌 신청
Patel DS / 2017 / Modeling and simulation of bacterial outer membranes and interactions with membrane proteins / Curr. Opin. Struct. Biol 43:131~140
May KL / 2017 / Making a membrane on the other side of the wall / Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1862:1386~1393
Grabowicz M / 2018 / Lipoprotein transport : greasing the machines of outer membrane biogenesis : re-examining lipoprotein transport mechanisms among diverse Gramnegative bacteria while exploring new discoveries and questions / BioEssays 40:e1700187
Typas A / 2010 / Regulation of peptidoglycan synthesis by outer-membrane proteins / Cell 143:1097~1109
Paradis-Bleau C / 2010 / Lipoprotein cofactors located in the outer membrane activate bacterial cell wall polymerases / Cell 143:1110~1120
May KL / 2017 / Making a membrane on the other side of the wall / Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1862:1386~1393
Grabowicz M / 2018 / Lipoprotein transport : greasing the machines of outer membrane biogenesis : re-examining lipoprotein transport mechanisms among diverse Gramnegative bacteria while exploring new discoveries and questions / BioEssays 40:e1700187
Typas A / 2010 / Regulation of peptidoglycan synthesis by outer-membrane proteins / Cell 143:1097~1109
Paradis-Bleau C / 2010 / Lipoprotein cofactors located in the outer membrane activate bacterial cell wall polymerases / Cell 143:1110~1120
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