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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 615 - 620 (6page)
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Objective Black sticky rice with giant embryo (BSRGE) contains high GABA content and affects alcohol-related indices among social drinkers, and alcohol intake and anxiety-related behavior of mice. However, it is unknown whether the intake of BSRGE affects GABAergic activity of brain directly. The purpose of this study is to elucidate the effect of oral administration of BSRGE on brain GABA concentrations compared with commercially available GABA compound and regular feeds. Methods Twenty-one male C57BL/6 mice were assigned to BSRGE, a regular feed (AIN-76) lacking GABA, and a regular feed containing GABA compound. After feeding freely for 48 h, the cortex and striatum were separated from the brain. An enzyme-linked immunosorbent assay was conducted to measure GABA and glutamate concentrations in mouse brain. Results The GABA concentration of the BSRGE group was higher than that of regular feed and GABA compound group (p<0.001). However, the GABA compound group showed no significant difference from the regular feed group (p=0.50). Conclusion Intake of BSRGE containing high GABA content increased GABA concentrations in mouse brain compared with regular feed unlike GABA compound. The results of this study constitute an important basis for further investigations into the clinical applications of BSRGE.
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참고문헌 (32)
참고문헌 신청
Bormann J / 2000 / The ‘ABC’ of GABA receptors / Trends Pharmacol Sci 21:16~19
Nutt D / 2006 / GABAA receptors : subtypes, regional distribution, and function / J Clin Sleep Med 2:S7~S11
Al-Sarraf H / 2002 / Transport of 14C-gamma-aminobutyric acid into brain, cerebrospinal fluid and choroid plexus in neonatal and adult rats / Brain Res Dev Brain Res 139:121~129
Grobin AC / 1998 / The role of GABA(A)receptors in the acute and chronic effects of ethanol / Psychopharmacology(Berl) 139:2~19
Kalueff AV / 2007 / Role of GABA in anxiety and depression / Depress Anxiety 24:495~517
Nutt D / 2006 / GABAA receptors : subtypes, regional distribution, and function / J Clin Sleep Med 2:S7~S11
Al-Sarraf H / 2002 / Transport of 14C-gamma-aminobutyric acid into brain, cerebrospinal fluid and choroid plexus in neonatal and adult rats / Brain Res Dev Brain Res 139:121~129
Grobin AC / 1998 / The role of GABA(A)receptors in the acute and chronic effects of ethanol / Psychopharmacology(Berl) 139:2~19
Kalueff AV / 2007 / Role of GABA in anxiety and depression / Depress Anxiety 24:495~517
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