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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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The aim of this study was to evaluate gamma-aminobutyric acid (GABA)-induced erythropoietin (EPO) and EPO-receptor expression in human Hep3B cells and Sprague Dawley (SD) rats during hypoxia. Expression levels of EPO, EPO-R mRNA, Janus kinase-2 (JAK-2), vascular endothelial growth factor (VEGF), hypoxia inducible factor-1 (HIF-1), and HIF-2 in response to GABA treatment were evaluated in cell lines. SD rats were randomly divided into 5 groups of 8 rats each, and GABA was orally administered; the groups were the normal control (NC), hypoxia-exposed (G0), as well as the GABA 1 mg/100 g body weight (BW) GABA treated group (G1), 5 mg/100 g BW GABA treated group (G5), and 10 mg/100 g BW GABA treated group (G10) with hypoxia. We analyzed EPO levels and red blood cell counts in rat blood and EPO gene expression in kidney tissue. EPO and VEGF mRNA levels in Hep3B cells exposed to hypoxia were significantly increased and further increased after GABA treatment. However, the expression of EPO-R and JAK-2 mRNAs were not affected by GABA, but hypoxia-induced HIF-1 and HIF-2 mRNA expression was inhibited by GABA. In the kidney tissue of rats exposed to hypoxia, the expression level of EPO mRNA was greatly increased, but levels in the GABA treatment groups significantly decreased. EPO levels in the serum showed the same significant trend, but the red blood cell counts were not significantly different. These findings demonstrate that HIF-1 and HIF-2 activation increase EPO expression in Hep3B cells exposed to hypoxia. However HIF decreased by GABA addition and VEGF increased significantly.
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REFERENCES
참고문헌 (31)
참고문헌 신청
Arne S / 2007 / GABA : Homeostatic and pharmacological aspects / Progress in Brain Research 3:320~336
Buemi M / 2003 / The pleiotropic effects of erythropoietin in the central nervous system / Journal of Neuropathology & Experimental Neurology 62:228~236
Chapman RF / 1998 / Individual variation in response to altitude training / Journal of Applied Physiology 85:1448~1456
Chatterjee PK / 2007 / Novel pharmacological approaches to the treatment of renal ischemia-reperfusion injury : a comprehensive review / Naunyn-Schmiedeberg's Archives of Pharmacology 376:1~43
Dulmovits BM / 2017 / Characterization, regulation and targeting of erythroid progenitors in normal and disordered human erythropoiesis / Current Opinion in Hematology 24:159
Buemi M / 2003 / The pleiotropic effects of erythropoietin in the central nervous system / Journal of Neuropathology & Experimental Neurology 62:228~236
Chapman RF / 1998 / Individual variation in response to altitude training / Journal of Applied Physiology 85:1448~1456
Chatterjee PK / 2007 / Novel pharmacological approaches to the treatment of renal ischemia-reperfusion injury : a comprehensive review / Naunyn-Schmiedeberg's Archives of Pharmacology 376:1~43
Dulmovits BM / 2017 / Characterization, regulation and targeting of erythroid progenitors in normal and disordered human erythropoiesis / Current Opinion in Hematology 24:159
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