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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 106 - 116 (11page)
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Objectives: Hypoxia—a characteristic of almost all types of solid tumors—has been associated with poor outcomes in several human malignancies. Genipin—an active constituent of Gardenia fruit— has been reported to exert an anti-tumor effect in several cancers. In this study, we investigated inhibition of angiogenesis using Genipin-mediated hypoxia-induced hypoxia inducible factor (HIF-1) and VEGF expression in human cervical cancer cells. Methods: Under normoxic and hypoxic conditions, the expression of HIF-1α and VEGF in cervical cancer HeLa cells was detected by quantitative reverse transcription polymerase chain reaction and western blotting. Luciferase reporter assays were used to investigate the molecular mechanisms underlying the hypoxia-induced survivin activation. Results: Surprisingly, we found that Genipin suppressed the HIF-1α accumulation during hypoxia in human liver cancer cell line (HepG2), human prostate cancer cell line (LNCaP), colon cancer cell line (HCT116), and breast cancer cell line (MDA231). Genipin treatment also significantly reduced hypoxia-induced secretion of VEGF. Conclusions: Suppression of HIF-1α accumulation following treatment with Genipin under hypoxia was associated with PI3K and MAPK pathways. Taken together, these results suggested that Genipin inhibits HIF-1α expression through inhibition of PI3K and MAPK signaling pathways. These results provide new insights into a potential mechanism of the anticancer properties of Genipin
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참고문헌 (12)
참고문헌 신청
Folkman J. / 2002 / Role of angiogenesis in tumor growth and metastasis / Semin Oncol 29:15~18
Ferrara N / 1996 / Vascular endothelial growth factor, a specific regulator of angiogenesis / Curr Opin Nephrol Hypertens 5:35~44
Krishnamachary B / 2003 / Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1 / Cancer Res 63:1138~1143
Fang J / 2007 / Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression / Carcinogenesis 28:858~864
Garcia-Maceira P / 2009 / Silibinin inhibits hypoxia-inducible factor-1alpha and mTOR/p 70S6K/4E-BP1 signalling pathway in human cervical and hepatoma cancer cells:implications for anticancer therapy / Oncogene 28:313~324
Ferrara N / 1996 / Vascular endothelial growth factor, a specific regulator of angiogenesis / Curr Opin Nephrol Hypertens 5:35~44
Krishnamachary B / 2003 / Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1 / Cancer Res 63:1138~1143
Fang J / 2007 / Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression / Carcinogenesis 28:858~864
Garcia-Maceira P / 2009 / Silibinin inhibits hypoxia-inducible factor-1alpha and mTOR/p 70S6K/4E-BP1 signalling pathway in human cervical and hepatoma cancer cells:implications for anticancer therapy / Oncogene 28:313~324
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