Is Biochemical Follow Up Possible in Peripheral Arterial Disease Treatment: Hypoxia Inducible Factor-1 Alpha?

Cihan Yücel; Mete Gürsoy; Serkan Ketenciler; Aslıhan Tenekeciğil; Feryaz Kızıltan; Nihan Kayalar

doi:10.5758/vsi.210011

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자료유형: 학술저널

저자정보: Cihan Yücel (Department of Cardiovascular Surgery Prof Dr Cemil Tascıoglu City Hospital İstanbul Turkey) Mete Gürsoy (Department of Cardiovascular Surgery Prof Dr Cemil Tascıoglu City Hospital İstanbul Turkey) Serkan Ketenciler (Department of Cardiovascular Surgery Prof Dr Cemil Tascıoglu City Hospital İstanbul Turkey) Aslıhan Tenekeciğil (Medical Laboratory Bağcılar Training and Research Hospital İstanbul Turkey) Feryaz Kızıltan (Department of Cardiovascular Surgery Prof Dr Cemil Tascıoglu City Hospital İstanbul Turkey) Nihan Kayalar (Department of Cardiovascular Surgery Prof Dr Cemil Tascıoglu City Hospital İstanbul Turkey)

저널정보: 대한혈관외과학회 Vascular Specialist International Vascular Specialist International Vol.37 No.3

발행연도: 2021.9

수록면: 29 - 29 (1page)

DOI: 10.5758/vsi.210011

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Purpose: The hypoxia inducible factor (HIF)-1 is a dimeric protein complex that plays an integral role in the body’s response to hypoxia. This study aimed to analyze the regulation of HIF-1α following vascular and/or endovascular surgery in peripheral arterial disease (PAD) patients. Materials and Methods: A total of 40 patients with PAD (≥Rutherford category 3) were included in this prospective study. The mean age was 61.9±9.2 years. Open surgery was performed in 16 patients, and endovascular intervention was performed in 34 patients. At preoperative (T1), postoperative day 1 (T2), and month 3 (T3), the serum HIF-1α levels were checked using the ELISA technique. Results: At T3, the ankle-brachial index was significantly higher than the preoperative value (P<0.001). Serum HIF-1α levels at T1, T2, and T3 were 2.0±1.7 ng/mL, 1.9±1.7 ng/mL, and 1.6±1.4 ng/mL, respectively. Serum HIF-1α levels between T1 and T3 and between T2 and T3 were significantly different (P<0.05). The preoperative HIF-1α levels were lowest in iliac lesions compared to femoropopliteal or tibial lesions. Conclusion: The HIF-1α levels were decreased in all patients on postoperative days, T2 and T3, compared with the preoperative values. Our results indicated that HIF-1α may be a surrogate marker after revascularization in patients with PAD. Further studies are needed to analyze the sensitivity, specificity, and cut-off values of HIF-1α in patients with PAD.

#Hypoxia inducible factor 1α #Atherosclerosis #Peripheral arterial disease #Endovascular procedures #Reperfusion

참고문헌 (28)

참고문헌 신청

Ziello JE / 2007 / Hypoxia-Inducible factor(HIF)-1 regulatory pathway and its potential for therapeutic intervention in malignancy and ischemia / Yale J Biol Med 80:51~60

Gao L / 2012 / The role of hypoxia-inducible factor 1 in atherosclerosis / J Clin Pathol 65:872~876

Krock BL / 2011 / Hypoxia-induced angiogenesis : good and evil / Genes Cancer 2:1117~1133

Ho TK / 2006 / Hypoxia-inducible factor 1 in lower limb ischemia / Vascular 14:321~327

Semenza GL / 2007 / Vasculogenesis, angiogenesis, and ar ter iogenesis : mechanisms of blood vessel formation and remodeling / J Cell Biochem 102:840~847

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