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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 35 - 40 (6page)
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초록· 키워드
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AbstractObjective: Adriamycin (ADR) is an important anti-cancer drug which can cause renal toxicity. Given the known anti-inflammatory and antioxidant effects of Plantago major (P. major), the aim of this study was to determine the effects of hydroalcoholic extract of P. major on ADR- induced nephropathy in rats. Methods: Fifty male Wistar albino rats were randomly divided into 5 groups including: control, ADR (5 mg/kg), ADR + P. major (600 and 1200 mg/kg) and P. major (1200mg/kg). The animals were treated with P. major extract for 5 consecutive weeks and ADR was intravenously injected on the 7th day of the study. Urine and serum samples were collected on days 0, 14, 21, 28, and 35 for the measurement of serum cholesterol and albumin levels and urine protein excretion rate. At the end of the study, the left kidneys were removed for apoptosis assessment. Results: Administration of ADR significantly decreased serum albumin level and increased serum cholesterol and urine protein excretion rate as well as, apoptotic cell numbers compared to the control group (P < 0.001) while had no effect on glomerular filtration rate (P > 0.05). Treatment with P. major , in both 600 and 1200 mg/kg doses, increased serum albumin level and decreased serum cholesterol concentration, urine protein excretion rate and as well as the number of apoptotic cell compared to the ADR group (P < 0.001). Conclusion: Our results showed that the P. majorextract effectively protects against ADR- induced nephropathy by reducing kidney apoptosis and improving renal functioning in rats.
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참고문헌 (24)
참고문헌 신청
Kaneko Y / 2013 / Nephritis and nephrotic syndrome / Jpn J Nephrol 55(1):35~41
El-Sayed ESM / 2017 / Alpha lipoic acid prevents doxorubicin-induced nephrotoxicity by mitigation of oxidative stress, inflammation, and apoptosis in rats / J Biochem Mol Toxicol 31(9):e21940
Ayla S / 2011 / Doxorubicin induced nephrotoxicity : protective effect of nicotinamide / Int J cell biol 2011:1~9
Mohebbati R / 2017 / Mixed hydroalcoholic extracts of Nigella sativa and Curcuma longa improves adriamycin-induced renal injury in rat / Saudi J Kidney Dis Transpl 28(6):1270
Heravi NE / 2018 / Doxorubicin-induced renal inflammation in rats : Protective role of Plantago major / Avicenna J phytomed 8(2):179
El-Sayed ESM / 2017 / Alpha lipoic acid prevents doxorubicin-induced nephrotoxicity by mitigation of oxidative stress, inflammation, and apoptosis in rats / J Biochem Mol Toxicol 31(9):e21940
Ayla S / 2011 / Doxorubicin induced nephrotoxicity : protective effect of nicotinamide / Int J cell biol 2011:1~9
Mohebbati R / 2017 / Mixed hydroalcoholic extracts of Nigella sativa and Curcuma longa improves adriamycin-induced renal injury in rat / Saudi J Kidney Dis Transpl 28(6):1270
Heravi NE / 2018 / Doxorubicin-induced renal inflammation in rats : Protective role of Plantago major / Avicenna J phytomed 8(2):179
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