지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Background : Treatment experiences with antiviral agents against MERS-CoV (Middle East Respiratory Syndrome Coronavirus) infection are limited, and there is lack of information regarding adverse drug reactions (ADRs) in this patient group. In 2015, we evaluated the ADRs of antiviral treatment against MERS-CoV infections in one tertiary teaching hospital in South Korea.
Methods : Between May 20th and July 20th 2015, a retrospective chart review was conducted to evaluate any ADRs. We focused on three antiviral agents: ribavirin, peginterferon alpha2a and lopinavir/ritonavir. Laboratory data and clinical implications of ADRs were collected through electronic medical records. The ADRs were evaluated and cross checked by three independent pharmacists.
Results : Totally, 28 patients were evaluated, and 15 ADRs were detected. Ribavirin was the most causative agent. Hematologic ADRs were the maximum reported, and nausea/vomiting was second ranked. Seven ADRs were scored as Grade 3 severity of ADRs, as per the CTCAE ver. 4.0; the causative drug was discontinued in 9 cases. Causality scores using WHO-UMC and Naranjo scale indicated that most of the ADR cases had a‘ possible’relationship.
Conclusion : ADR patterns of the three drugs evaluated for MERS-CoV patients were mostly similar with the limited existing reports.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
2015 / MERS 항바이러스제 치료지침 / 대한감염학회
American Society of Health-system Pharmacists / 2015 / AHFS Drug Information, 2015 / ASHP :620~790
Omrani AS / 2014 / Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study / Lancet Infect Dis 14:1090~1095
Chiou HE / 2005 / Adverse effects of ribavirin and outcome in severe acute respiratory syndrome: experience in two medical centers / Chest 128:263~272
Knowles SR / 2003 / Common adverse events associated with the use of ribavirin for severe acute respiratory syndrome in Canada / Clin Infect Dis 37:1139~1142
American Society of Health-system Pharmacists / 2015 / AHFS Drug Information, 2015 / ASHP :620~790
Omrani AS / 2014 / Ribavirin and interferon alfa-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study / Lancet Infect Dis 14:1090~1095
Chiou HE / 2005 / Adverse effects of ribavirin and outcome in severe acute respiratory syndrome: experience in two medical centers / Chest 128:263~272
Knowles SR / 2003 / Common adverse events associated with the use of ribavirin for severe acute respiratory syndrome in Canada / Clin Infect Dis 37:1139~1142
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