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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제6호
- 발행연도
- 2019.1
- 수록면
- 845 - 855 (11page)
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초록· 키워드
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Synthetic biology builds programmed biological systems for a wide range of purposes such as improving human health, remedying the environment, and boosting the production of valuable chemical substances. In recent years, the rapid development of synthetic biology has enabled synthetic bacterium-based diagnoses and therapeutics superior to traditional methodologies by engaging bacterial sensing of and response to environmental signals inherent in these complex biological systems. Biosynthetic systems have opened a new avenue of disease diagnosis and treatment. In this review, we introduce designed synthetic bacterial systems acting as living therapeutics in the diagnosis and treatment of several diseases. We also discuss the safety and robustness of genetically modified synthetic bacteria inside the human body.
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참고문헌 (65)
참고문헌 신청
Cameron DE / 2014 / A brief history of synthetic biology / Nat Rev. Microbiol 12:381~390
Chubukov V / 2016 / Synthetic and systems biology for microbial production of commodity chemicals / NPJ Syst. Biol. Appl 2:16009
Paddon CJ / 2014 / Semi-synthetic artemisinin : a model for the use of synthetic biology in pharmaceutical development / Nat. Rev. Microbiol 12:355~367
Lee SK / 2008 / Metabolic engineering of microorganisms for biofuels production : from bugs to synthetic biology to fuels / Curr. Opin. Biotechnol 19:556~563
김송이 / 2018 / Current Status of Microbial Phenylethanoid Biosynthesis / Journal of Microbiology and Biotechnology 28(8):1225~1232
Chubukov V / 2016 / Synthetic and systems biology for microbial production of commodity chemicals / NPJ Syst. Biol. Appl 2:16009
Paddon CJ / 2014 / Semi-synthetic artemisinin : a model for the use of synthetic biology in pharmaceutical development / Nat. Rev. Microbiol 12:355~367
Lee SK / 2008 / Metabolic engineering of microorganisms for biofuels production : from bugs to synthetic biology to fuels / Curr. Opin. Biotechnol 19:556~563
김송이 / 2018 / Current Status of Microbial Phenylethanoid Biosynthesis / Journal of Microbiology and Biotechnology 28(8):1225~1232
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