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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제22권 제4호
- 발행연도
- 2019.1
- 수록면
- 358 - 368 (11page)
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초록· 키워드
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Purpose: Pediatric Crohn's disease (CD) is directly related to growth and has a high probability of requiring surgical intervention(s); therefore, more active treatment for CD is required for children. This study investigated the impact of biologics on growth and disease course associated with surgery. Methods: This was a retrospective cohort study involving patients diagnosed with CD at the Seoul National University Children's Hospital (Seoul, Korea) between January 2006 and October 2017. The aim was to determine the characteristics of pediatric patients with CD and whether biologics affected growth and the surgical disease course. Results: Among patients who underwent surgery for CD, the mean number of operations per patient was 1.89. The mean time from initial diagnosis to surgery was 19.3 months. The most common procedure was fistulectomy (34%), followed by incision and drainage (25%). In all patients, the use of biologics increased the height ( p =0.002) and body mass index (BMI) ( p =0.005). Among patients who underwent surgery, height ( p =0.004) and BMI ( p =0.048) were increased in the group using biologics. Patients who used biologics exhibited a low operation rate only within 2 years after diagnosis, with no differences thereafter ( p =0.027). Conclusion: Although biologics could not mitigate the operation rate in pediatric patients who underwent surgery for CD, biological therapy delayed disease progression within 2 years of disease onset. Additionally, biologics conferred growth and BMI benefits in this window period. Therefore, it may be helpful to use biologics for optimal growth in pediatric patients with a high probability of undergoing future surgery.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Lee YJ / 2010 / The principles of drug therapy of Crohn's disease in child and adolescent / Korean J Pediatr Gastroenterol Nutr 13:S59~S69
Ng SC / 2013 / Incidence and phenotype of inflammatory bowel disease based on results from the Asia-pacific Crohn's and colitis epidemiology study / Gastroenterology 145:158~165.e2
Polito JM 2nd / 1996 / Crohn's disease : influence of age at diagnosis on site and clinical type of disease / Gastroenterology 111:580~586
Cuffari C / 2005 / Crohn's jejunoileitis : the pediatrician's perspective on diagnosis and management / Inflamm Bowel Dis 11:696~704
Young Ah Lee / 2016 / Clinical Features and Extraintestinal Manifestations of Crohn Disease in Children / Pediatric Gastroenterology, Hepatology & Nutrition 19(4):236~242
Ng SC / 2013 / Incidence and phenotype of inflammatory bowel disease based on results from the Asia-pacific Crohn's and colitis epidemiology study / Gastroenterology 145:158~165.e2
Polito JM 2nd / 1996 / Crohn's disease : influence of age at diagnosis on site and clinical type of disease / Gastroenterology 111:580~586
Cuffari C / 2005 / Crohn's jejunoileitis : the pediatrician's perspective on diagnosis and management / Inflamm Bowel Dis 11:696~704
Young Ah Lee / 2016 / Clinical Features and Extraintestinal Manifestations of Crohn Disease in Children / Pediatric Gastroenterology, Hepatology & Nutrition 19(4):236~242
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