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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 365 - 368 (4page)
이용수
초록· 키워드
오류제보하기
Pyoderma gangrenosum (PG) is an uncommon extra-intestinal manifestation of inflammatory bowel disease (IBD). Despitelimited published literature, biologics have caused a paradigm shift in the management of this difficult-to-treat skin condition. The clinical data and outcomes of three patients with active ulcerative colitis and concurrent PG treated with biologics (infliximabtwo and adalimumab one) are reviewed in this report. Biologics were added because of the sub-optimal response of thecolonic symptoms and skin lesions to parenteral hydrocortisone therapy. All three patients showed a dramatic response to theaddition of the biologics. In view of the rapid healing of the skin lesions, superior response rate, and the additional benefit of improvementin the underlying colonic disease following treatment, anti-tumor necrosis factor blockers should be considered asa first line therapy in the management of PG with underlying IBD.
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등록된 정보가 없습니다.
참고문헌 (10)
참고문헌 신청
Menachem Y / 2004 / Clinical manifestations of pyoderma gangrenosum associated with inflammatory bowel disease / Isr Med Assoc J 6:88~90
Rothfuss KS / 2006 / Extraintestinal manifestations and complications in inflammatory bowel diseases / World J Gastroenterol 12:4819~4831
Chow RK / 1996 / Treatment of pyoderma gangrenosum / J Am Acad Dermatol 34:1047~1060
Brooklyn T / 2006 / Diagnosis and treatment of pyoderma gangrenosum / BMJ 333:181~184
Brooklyn TN / 2006 / Infliximab for the treatment of pyoderma gangrenosum: a randomised, double blind, placebo controlled trial / Gut 55:505~509
Rothfuss KS / 2006 / Extraintestinal manifestations and complications in inflammatory bowel diseases / World J Gastroenterol 12:4819~4831
Chow RK / 1996 / Treatment of pyoderma gangrenosum / J Am Acad Dermatol 34:1047~1060
Brooklyn T / 2006 / Diagnosis and treatment of pyoderma gangrenosum / BMJ 333:181~184
Brooklyn TN / 2006 / Infliximab for the treatment of pyoderma gangrenosum: a randomised, double blind, placebo controlled trial / Gut 55:505~509
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