지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 147 - 153 (7page)
이용수
초록· 키워드
오류제보하기
Objectives: Many studies have been reported the efficacy of intravenous lipid emulsion (ILE) as an antidote on acute lipophilic drug toxicity. Clozapine, highly lipophilic dibenzodiazepine neuroleptics, is an important medication in the schizophrenia therapy regimen. Acute intoxication with antipsychotics is one of the main reasons for the referral of poisoned patients to the hospital. We expected that ILE could be used for the therapy of acute clozapine intoxicated patients. Methods: We used two groups of consisting of six male rats. Both groups received a toxic dose of clozapine (40 mg/kg) intravenously, via the tail vein. After 15 minutes, they were treated with intravenous infusion of 18.6 mg/ kg normal saline (NS group), or 18.6 mg/kg ILE 20% (ILE group). We evaluated blood pressure (BP) and heart rate by power lab apparatus through the tail artery, ataxia by a rat rotary circle, seizure scores and death in multiple times after starting clozapine administration. For bio-chemical and pathological evaluations the samples of tissue and blood were taken. Results: Our results demonstrated that ILE 20% could return hypotension-induced clozapine better than normal saline. Furthermore, ataxia and seizure have rectified more rapidly and deaths reduced. Clozapine administration causes pancreatitis and lung injury but fat emulsion did not show an optimal effect on tissue damages caused by clozapine toxicity. Conclusion: In conclusion, ILE can remove toxic signs of clozapine same as other lipophilic medicines, however, clinical uses of ILE for this intention requires more appraisement to determine the precise implication and safety.
목차
등록된 정보가 없습니다.
참고문헌 (49)
참고문헌 신청
Aksel G / 2015 / Intravenous Lipid Emulsion Therapy for Acute Synthetic Cannabinoid Intoxication: Clinical Experience in Four Cases / Case reports in emergency medicine 2015:180921
Barton CA / 2015 / Hendrickson R. Successful treatment of a massive metoprolol overdose using intravenous lipid emulsion and hyperinsulinemia/euglycemia therapy / Pharmacotherapy 35(5):e56~e60
Herring JM / 2015 / Intravenous lipid emulsion therapy in three cases of canine naproxen overdose / J Vet Emerg Crit Care(San Antonio)
Brull SJ / 2008 / Lipid emulsion for the treatment of local anesthetic toxicity : patient safety implications / Anesthesia and analgesia 106(5):1337~1339
Burch MS / 2011 / Treatment of local-anesthetic toxicity with lipid emulsion therapy / American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 68(2):125~129
Barton CA / 2015 / Hendrickson R. Successful treatment of a massive metoprolol overdose using intravenous lipid emulsion and hyperinsulinemia/euglycemia therapy / Pharmacotherapy 35(5):e56~e60
Herring JM / 2015 / Intravenous lipid emulsion therapy in three cases of canine naproxen overdose / J Vet Emerg Crit Care(San Antonio)
Brull SJ / 2008 / Lipid emulsion for the treatment of local anesthetic toxicity : patient safety implications / Anesthesia and analgesia 106(5):1337~1339
Burch MS / 2011 / Treatment of local-anesthetic toxicity with lipid emulsion therapy / American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 68(2):125~129
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
베라파밀 중독의 쥐 모델에서 지방에멀젼 정맥주사의 효과
대한임상독성학회지
2018 .01
-
Associations of Serum Isoleucine with Mild Cognitive Impairment and Alzheimer’s Disease
Annals of geriatric medicine and research
2024 .09
-
Intravenous lipid emulsion therapy for cardiac arrest and refractory ventricular tachycardia due to multiple herb intoxication
Clinical and Experimental Emergency Medicine
2019 .01
-
Acute and sub-acute oral toxicity study of multi-mineral compound in rats
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Acute and Repeated 28-Day Oral Dose Toxicity Studies of Thymus vulgaris L. Essential Oil in Rats
Toxicological Research
2019 .07
-
Acute and repeated dose 26-week oral toxicity study of 20(S)-ginsenoside Rg3 in Kunming mice and Sprague-Dawley rats
Journal of Ginseng Research
2020 .03
-
Lipid emulsion therapy of local anesthetic systemic toxicity due to dental anesthesia
Journal of dental anesthesia and pain medicine
2019 .01
-
Glutathione S-transferase T1, M1 and P1 Genetic Polymorphisms and Susceptibility to Colorectal Cancer in Turkey
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Toxicological assessment of Bromochlorophene: single and repeated-dose 28-day oral toxicity study in Sprague–Dawley rats
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Influence of clozapine on neurodevelopmental protein expression and behavioral patterns in animal model of psychiatric disorder induced by low-level of lead
The Korean Journal of Physiology & Pharmacology
2019 .01
-
벤조피렌의 급성독성시험 연구
한국산업보건학회지
2018 .01
-
Mechanisms underlying lipid emulsion resuscitation for drug toxicity: a narrative review
Korean Journal of Anesthesiology
2023 .06
-
Reproductive and Developmental Toxicity Screening Test of Ethyl Hydrogen Adipate in Rats
Toxicological Research
2016 .10
-
LD50 estimations for alternative animal studies using IC50 in HepG2 and iPSC-derived hepatocytes
한국실험동물학회 학술발표대회 논문집
2022 .01
-
A Study on the Single-dose Oral Toxicity of Super Key in Sprague-Dawley Rats
Journal of Pharmacopuncture
2015 .01
-
Clozapine Induced Neuroleptic Malignant Syndrome
Acute and Critical Care
2017 .08
-
Single dose oral toxicity study of a water extract of Gekko gecko in Sprague-Dawley rats
Journal of Biomedical and Translational Research
2024 .06
-
Lipid emulsion treatment for ventricular tachycardia induced by the toxicity of multiple herbs
Clinical and Experimental Emergency Medicine
2020 .01
-
Acute pulmonary toxicity and inflammation induced by the mixtures of household chemicals in rats
한국실험동물학회 학술발표대회 논문집
2015 .02
-
Toxicity and Safety Profiles of Methanolic Extract of Pistacia integerrima J. L. Stewart ex Brandis (PI) for Wistar Rats
Journal of Pharmacopuncture
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0