지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 628 - 636 (9page)
이용수
초록· 키워드
오류제보하기
Altered genetic features in cancer cells lead to a high rate of aerobic glycolysis and metabolic reprogramming that is essential for increased cancer cell viability and rapid proliferation. Pyruvate kinase muscle (PKM) is a rate-limiting enzyme in the final step of glycolysis. Herein, we report that PKM is a potential therapeutic target in triple-negative breast cancer (TNBC) cells. We found that PKM1 or PKM2 is highly expressed in TNBC tissues or cells. Knockdown of PKM significantly suppressed cell proliferation and migration, and strongly reduced S phase and induced G2 phase cell cycle arrest by reducing phosphorylation of the CDC2 protein in TNBC cells. Additionally, knockdown of PKM significantly suppressed NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity by reducing the phosphorylation of p65 at serine 536, and also decreased the expression of NF-kB target genes. Taken together, PKM is a potential target that may have therapeutic implications for TNBC cells.
목차
등록된 정보가 없습니다.
참고문헌 (43)
참고문헌 신청
Anastasiou, D. / 2011 / Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses / Science 334:1278~1283
Azoitei, N. / 2016 / PKM2 promotes tumor angiogenesis by regulating HIF-1alpha through NF-kappaB activation / Mol. Cancer 15:3
Barbie, T. U. / 2014 / Targeting an IKBKE cytokine network impairs triple-negative breast cancer growth / J. Clin. Invest 124:5411~5423
Bianchini, G. / 2016 / Triple-negative breast cancer : challenges and opportunities of a heterogeneous disease / Nat. Rev. Clin. Oncol 13:674~690
Bonotto, M. / 2014 / Measures of outcome in metastatic breast cancer : insights from a real-world scenario / Oncologist 19:608~615
Azoitei, N. / 2016 / PKM2 promotes tumor angiogenesis by regulating HIF-1alpha through NF-kappaB activation / Mol. Cancer 15:3
Barbie, T. U. / 2014 / Targeting an IKBKE cytokine network impairs triple-negative breast cancer growth / J. Clin. Invest 124:5411~5423
Bianchini, G. / 2016 / Triple-negative breast cancer : challenges and opportunities of a heterogeneous disease / Nat. Rev. Clin. Oncol 13:674~690
Bonotto, M. / 2014 / Measures of outcome in metastatic breast cancer : insights from a real-world scenario / Oncologist 19:608~615
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
A thiosemicarbazone derivative induces triple negative breast cancer cell apoptosis: possible role of miRNA‑125a‑5p and miRNA‑181a‑5p
Genes & Genomics
2019 .01
-
Tazarotene-Induced Gene 1 Interacts with DNAJC8 and Regulates Glycolysis in Cervical Cancer Cells
Molecules and Cells
2018 .06
-
RBBP4 plays a vital role in the malignant progression of triple-negative breast cancer by regulating epithelial-mesenchymal transition
Genes & Genomics
2022 .10
-
Study of mitochondria depolarization by plasma activated medium on cancer cell lines
한국진공학회 학술발표회초록집
2021 .02
-
Microtubule Acetylation-Specific Inhibitors Induce Cell Death and Mitotic Arrest via JNK/AP-1 Activation in Triple-Negative Breast Cancer Cells
Molecules and Cells
2023 .06
-
Inhibition of cell growth by cellular differentiation into adipocyte-like cells in dexamethasone sensitive cancer cell lines
Animal cells and systems
2018 .01
-
Cell Death Inhibition Effect of Antioxidant Activity by 630 and 850 nm LEDs in RAW264.7 Cells
Current Optics and Photonics
2024 .10
-
LncRNA PVT1 influences breast cancer cells glycolysis through sponging miR-145-5p
Genes & Genomics
2023 .05
-
Ethanol extract of Innotus obliquus (Chaga mushroom) induces G1 cell cycle arrest in HT-29 human colon cancer cells
Nutrition Research and Practice
2015 .04
-
Ethanol extract of Innotus obliquus (Chaga mushroom) induces G1 cell cycle arrest in HT-29 human colon cancer cells
Nutrition Research and Practice
2015 .04
-
The RUNX1 Enhancer Element eR1: A Versatile Marker for Adult Stem Cells
Molecules and Cells
2020 .01
-
Morphological Image Processing of Bioceramic Foam
Quantitative Bio-Science
2017 .11
-
miRNA-195-5p/PSAT1 feedback loop in human triple-negative breast cancer cells
Genes & Genomics
2023 .01
-
Effect of Alternative Magnetic Field on the Cancer Cells
한국자기학회 학술연구발표회 논문개요집
2016 .11
-
A study to find a new specific target for triple-negative breast cancer therapy
한국분석과학회 학술대회
2022 .11
-
Fabrication of a 3D cell chip for evaluation of anticancer drug on cancer cell
한국진공학회 학술발표회초록집
2016 .08
-
The effects of human milk proteins on the proliferation of normal, cancer and cancer stem like cells
분석과학
2018 .12
-
Frequency Effect on Proliferation of Human Liver Cancer Cells under Alternating Magnetic Field
Journal of Magnetics
2020 .12
-
Brief guide to senescence assays using cultured mammalian cells
Molecules and Cells
2024 .01
-
Single-Cell Toolkits Opening a New Era for Cell Engineering
Molecules and Cells
2021 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0