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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 62 - 70 (9page)
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초록· 키워드
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Xylitol is well-known to have an anti-caries effect by inhibiting the replication of cariogenic bacteria. In addition, xylitol enhances saliva secretion. However, the precise molecular mechanism of xylitol on saliva secretion is yet to be elucidated. Thus, in this study, we aimed to investigate the stimulatory effect of xylitol on saliva secretion and to further evaluate the involvement of xylitol in muscarinic type 3 receptor (M3R) signaling. For determining these effects, we measured the saliva flow rate following xylitol treatment in healthy individuals and patients with dry mouth. We further tested the effects of xylitol on M3R signaling in human salivary gland (HSG) cells using real-time quantitative reverse-transcriptase polymerase chain reaction, immunoblotting, and immunostaining. Xylitol candy significantly increased the salivary flow rate and intracellular calcium release in HSG cells via the M3R signaling pathway. In addition, the expressions of M3R and aquaporin 5 were induced by xylitol treatment. Lastly, we investigated the distribution of M3R and aquaporin 5 in HSG cells. Xylitol was found to activate M3R, thereby inducing increases in Ca 2+ concentration. Stimulation of the muscarinic receptor induced by xylitol activated the internalization of M3R and subsequent trafficking of aquaporin 5. Taken together, these findings suggest a molecular mechanism for secretory effects of xylitol on salivary epithelial cells.
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참고문헌 (29)
참고문헌 신청
J W Putney / 1986 / Identification of Cellular Activation Mechanisms Associated with Salivary Secretion / Annual Review of Physiology 48(1):75~88
L. J. Dawson / 2006 / Antimuscarinic antibodies in primary Sjögren's syndrome reversibly inhibit the mechanism of fluid secretion by human submandibular salivary acinar cells / Arthritis & Rheumatism 54(4):1165~1173
Takeshi Nakamura / 2004 / M(3) muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice / J Physiol 558(2):561~575
Toshimi Hattori / 2007 / Calcium antagonists cause dry mouth by inhibiting resting saliva secretion / Life Sciences 81(8):683~690
Tonghui Ma / 1999 / Defective Secretion of Saliva in Transgenic Mice Lacking Aquaporin-5 Water Channels / Journal of Biological Chemistry 274(29):20071~20074
L. J. Dawson / 2006 / Antimuscarinic antibodies in primary Sjögren's syndrome reversibly inhibit the mechanism of fluid secretion by human submandibular salivary acinar cells / Arthritis & Rheumatism 54(4):1165~1173
Takeshi Nakamura / 2004 / M(3) muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice / J Physiol 558(2):561~575
Toshimi Hattori / 2007 / Calcium antagonists cause dry mouth by inhibiting resting saliva secretion / Life Sciences 81(8):683~690
Tonghui Ma / 1999 / Defective Secretion of Saliva in Transgenic Mice Lacking Aquaporin-5 Water Channels / Journal of Biological Chemistry 274(29):20071~20074
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