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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제17권 제1호
- 발행연도
- 2019.1
- 수록면
- 74 - 79 (6page)
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초록· 키워드
오류제보하기
Objective: Myostatin is a growth factor which is investigated regarding musculoskeletal system. Albeit its effect on muscle mass is known, it is considered likely having other unknown effects as well, particularly on central nervous system. With this study, it is aimed to find out that what type of effect electroconvulsive therapy (ECT) does on myostatin in patients with treatment resistant depression. Methods: Twenty-nine patients with treatment resistant major depression and thirty healthy volunteers were included in the study. Pre- and post-ECT levels of myostatine were compared; also this results were compared to healthy controls. Results: For 29 patients with treatment-resistant major depression, the pre-treatment mean myostatin level was 0.95±0.32 ng/ml and post-therapy myostatin level was 11.05±6.97 ng/ml. As a result of this study, it is found that ECT affects serum myostatin levels to a significant degree (t=4.17, p＜0.05). It is also found that there was a significant relation between serum myostatin levels and depression scores (r=0.392, p＜0.05). Conclusion: With the present study and similar ones, it can be understood that how ECT achieves its effectiveness biologically.
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등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Lee SJ / 1999 / Myostatin and the control of skeletal muscle mass / Curr Opin Genet Dev 9:604~607
Sharma M / 2001 / Myostatin in muscle growth and repair / Exerc Sport Sci Rev 29:155~158
Tsuchida K / 2008 / Targeting myostatin for therapies against muscle-wasting disorders / Curr Opin Drug Discov Devel 11:487~494
Kollias HD / 2008 / Transforming growth factor-beta and myostatin signaling in skeletal muscle / J Appl Physiol(1985) 104:579~587
Huang Z / 2011 / Myostatin : a novel insight into its role in metabolism, signal pathways, and expression regulation / Cell Signal 23:1441~1446
Sharma M / 2001 / Myostatin in muscle growth and repair / Exerc Sport Sci Rev 29:155~158
Tsuchida K / 2008 / Targeting myostatin for therapies against muscle-wasting disorders / Curr Opin Drug Discov Devel 11:487~494
Kollias HD / 2008 / Transforming growth factor-beta and myostatin signaling in skeletal muscle / J Appl Physiol(1985) 104:579~587
Huang Z / 2011 / Myostatin : a novel insight into its role in metabolism, signal pathways, and expression regulation / Cell Signal 23:1441~1446
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