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논문 기본 정보

자료유형
학술저널
저자정보
Akash Mitra (Stem Cells and Regenerative Medicine Centre Yenepoya Research Centre Yenepoya (Deemed to Be University) Deralakatte Karnataka India) Rizwan Qaisar (Department of Basic Medical Sciences College of Medicine University of Sharjah Sharjah United Arab Emirates) Bipasha Bose (Stem Cells and Regenerative Medicine Centre Yenepoya Research Centre Yenepoya (Deemed to Be University) Deralakatte Karnataka India) Sudheer Shenoy P (Stem Cells and Regenerative Medicine Centre Yenepoya Research Centre Yenepoya (Deemed to Be University) Deralakatte Karnataka India)
저널정보
대한골다공증학회 Osteoporosis and Sarcopenia Osteoporosis and Sarcopenia Vol.9 No.1
발행연도
2023.3
수록면
1 - 7 (7page)
DOI
10.1016/j.afos.2023.03.008

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Skeletal muscle is one of the leading frameworks of the musculo-skeletal system, which works in synergy with the bones. Long skeletal muscles provide stability and mobility to the human body and are primarily composed of proteins. Conversely, improper functioning of various skeletal muscles leads to diseases and disorders, namely, age-related muscle disorders called sarcopenia, a group of genetic muscle disorders such as muscular dystrophies, and severe muscle wasting in cancer known as cachexia. However, skeletal muscle has an excellent ability to undergo hypertrophy and enhanced functioning during sustained exercise over time. Indeed, these processes of skeletal muscle regeneration/hypertrophy, as well as degeneration and atrophy, involve an interplay of various signaling pathways. Myostatin is one such chemokine/myokine with a significant contribution to muscle regeneration or atrophy in multiple conditions. In this review, we try to put together the role and regulation of myostatin as a function of muscle regeneration extrapolated to multiple aspects of its molecular functions.

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