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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 716 - 732 (17page)
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The world is facing the new challenges of an aging population, and understanding the process of aging has therefore become one of the most important global concerns. Sarcopenia is a condition which is defined by the gradual loss of skeletal muscle mass and function with age. In research and clinical practice, sarcopenia is recognized as a component of geriatric disease and is a current target for drug development. In this review we define this condition and provide an overview of current therapeutic approaches. We further highlight recent findings that describe key pathophysiological phenotypes of this condition, including alterations in muscle fiber types, mitochondrial function, nicotinamide adenine dinucleotide (NAD+) metabolism, myokines, and gut microbiota, in aged muscle compared to young muscle or healthy aged muscle. The last part of this review examines new therapeutic avenues for promising treatment targets. There is still no accepted therapy for sarcopenia in humans. Here we provide a brief review of the current state of research derived from various mouse models or human samples that provide novel routes for the development of effective therapeutics to maintain muscle health during aging.
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참고문헌 (140)
참고문헌 신청
Population Division, Department of Economic and Social Affairs / 2019 / United Nations. World population aging, 2019highlights / United Nations :11~14
김규리 / 2020 / Impact of Skeletal Muscle Mass on Metabolic Health / Endocrinology and Metabolism 35(1):1~6
Hee-Won Jung / 2020 / Visualizing Domains of Comprehensive Geriatric Assessments to Grasp Frailty Spectrum in Older Adults with a Radar Chart / Annals of geriatric medicine and research 24(1):55~56
Cruz-Jentoft AJ / 2019 / Sarcopenia / Lancet 393:2636~2646
Chen X / 2014 / Frailty syndrome : an overview / Clin Interv Aging 9:433~441
김규리 / 2020 / Impact of Skeletal Muscle Mass on Metabolic Health / Endocrinology and Metabolism 35(1):1~6
Hee-Won Jung / 2020 / Visualizing Domains of Comprehensive Geriatric Assessments to Grasp Frailty Spectrum in Older Adults with a Radar Chart / Annals of geriatric medicine and research 24(1):55~56
Cruz-Jentoft AJ / 2019 / Sarcopenia / Lancet 393:2636~2646
Chen X / 2014 / Frailty syndrome : an overview / Clin Interv Aging 9:433~441
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