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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 63 - 63 (1page)
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초록· 키워드
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While aging, a person faces attenuation of general physical and mental health. Due to advances in science and technology, the life expectancy of people has increased dramatically and aging has gained an immense attention. In particular, a progressive muscle weakness during aging has gained extensive interest, and recently, researchers term this phenomenon as sarcopenia. Diverse approaches regarding the mechanism of sarcopenia and possible therapies have been studied vigorously in the last decade, and the Centers for Disease Control and Prevention (CDC) of the United States issued ICD-10-CM codes for sarcopenia in October 2016. PGC-1α is a master regulator of mitochondrial biogenesis. Reduced PGC-1α levels are associated to skeletal muscle weakness in aging or pathological conditions. Thus, elevating PGC-1α levels is a promising strategy to treat muscle aging. We performed high-throughput screening and identified two compounds, AMC#5023 and AMC#5114, as potent and safe inducer^_@span style=color:#999999 ^_# ... ^_@/span^_#^_@a href=javascript:; onclick=onClickReadNode('NODE10540193');fn_statistics('Z354','null','null'); style='color:#999999;font-size:14px;text-decoration:underline;' ^_#전체 초록 보기^_@/a^_#
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UCI(KEPA) : I410-ECN-0101-2021-528-001569372