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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 135 - 142 (8page)
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OCT4, also known as POU5F1 (POU domain class 5 transcription factor 1), is a transcription factor that acts as a master regulator of pluripotency in embryonic stem cells and is one of the reprogramming factors required for generating induced pluripotent stem cells. The human OCT4 encodes three isoforms, OCT4A, OCT4B, and OCT4B1, which are generated by alternative splicing. Currently, the functions and expression patterns of OCT4B remain largely unknown in malignancies, especially in human glioblastomas. Here, we demonstrated the function of OCT4B in human glioblastomas. Among the isoform of OCT4B, OCT4B-190 (OCT4B19kDa) was highly expressed in human glioblastoma stem cells and glioblastoma cells and was mainly detected in the cytoplasm rather than the nucleus. Overexpression of OCT4B19kDa promoted colony formation of glioblastoma cells when grown in soft agar culture conditions. Clinical data analysis revealed that patients with gliomas that expressed OCT4B at high levels had a poorer prognosis than patients with gliomas that expressed OCT4B at low levels. Thus, OCT4B19kDa may play a crucial role in regulating cancer cell survival and adaption in a rigid environment.
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참고문헌 (33)
참고문헌 신청
Abiko, K. / 2010 / Oct4 expression in immature teratoma of the ovary : relevance to histologic grade and degree of differentiation / Am. J. Surg. Pathol 34:1842~1848
Asadi, M. H. / 2011 / OCT4B1, a novel spliced variant of OCT4, is highly expressed in gastric cancer and acts as an antiapoptotic factor / Int. J. Cancer 128:2645~2652
Asadzadeh, J. / 2012 / A plausible anti-apoptotic role of up-regulated OCT4B1 in bladder tumors / Urol. J 9:574~580
Atlasi, Y. / 2008 / OCT4 spliced variants are differentially expressed in human pluripotent and nonpluripotent cells / Stem Cells 26:3068~3074
Ben-Porath, I. / 2008 / An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors / Nat. Genet 40:499~507
Asadi, M. H. / 2011 / OCT4B1, a novel spliced variant of OCT4, is highly expressed in gastric cancer and acts as an antiapoptotic factor / Int. J. Cancer 128:2645~2652
Asadzadeh, J. / 2012 / A plausible anti-apoptotic role of up-regulated OCT4B1 in bladder tumors / Urol. J 9:574~580
Atlasi, Y. / 2008 / OCT4 spliced variants are differentially expressed in human pluripotent and nonpluripotent cells / Stem Cells 26:3068~3074
Ben-Porath, I. / 2008 / An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors / Nat. Genet 40:499~507
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