지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.8
- 수록면
- 619 - 624 (6page)
- DOI
- molcells.2016.0118
이용수
초록· 키워드
오류제보하기
Glioblastoma stem cells (GBM-SCs) are believed to be a subpopulation within all glioblastoma (GBM) cells that are in large part responsible for tumor growth and the high grade of therapeutic resistance that is so characteristic of GBM. MicroRNAs (miR) have been implicated in regulating the expression of oncogenes and tumor suppressor genes in cancer stem cells, including GBM-SCs, and they are a potential target for cancer therapy. In the current study, miR-203 expression was reduced in CD133+ GBM-SCs derived from six human GBM biopsies. MicroRNA-203 transfected GBM-SCs had reduced capacity for self-renewal in the cell sphere assay and increased expression of glial and neuronal differentiation markers. In addition, a reduced proliferation rate and an increased rate of apoptosis were observed. Therefore, miR-203 has the potential to reduce features of stemness, specifically in GBM-SCs, and is a logical target for GBM gene therapy.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Bao, S. / 2006 / Glioma stem cells promote radioresistance by preferential activation of the DNA damage response / Nature 444:756~760
Beier, D. / 2007 / CD133(+)and CD133(-)glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles / Cancer Res 67:4010~4015
Beier, D. / 2008 / CD133 expression and cancer stem cells predict prognosis in high-grade oligodendroglial tumors / Brain Pathol 18:370~377
Chen, Z. / 2014 / MicroRNA-203 inhibits the proliferation and invasion of U251 glioblastoma cells by directly targeting PLD2 / Mol. Med. Rep 9:503~508
Chomczynski, P. / 2006 / The single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction : twenty-something years on / Nat. Protoc 1:581~585
Beier, D. / 2007 / CD133(+)and CD133(-)glioblastoma-derived cancer stem cells show differential growth characteristics and molecular profiles / Cancer Res 67:4010~4015
Beier, D. / 2008 / CD133 expression and cancer stem cells predict prognosis in high-grade oligodendroglial tumors / Brain Pathol 18:370~377
Chen, Z. / 2014 / MicroRNA-203 inhibits the proliferation and invasion of U251 glioblastoma cells by directly targeting PLD2 / Mol. Med. Rep 9:503~508
Chomczynski, P. / 2006 / The single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction : twenty-something years on / Nat. Protoc 1:581~585
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