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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 539 - 550 (12page)
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초록· 키워드
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Glioblastoma multiforme (GBM) is a fatal malignant tumor that is characterized by diffusive growth of tumor cells into the surrounding brain parenchyma. However, the diffusive nature of GBM and its relationship with the tumor microenvironment (TME) is still unknown. Here, we investigated the interactions of GBM with the surrounding microenvironment in orthotopic xenograft animal models using two human glioma cell lines, U87 and LN229. The GBM cells in our model showed different features on the aspects of cell growth rate during their development, dispersive nature of glioma tumor cells along blood vessels, and invasion into the brain parenchyma. Our results indicated that these differences in the two models are in part due to differences in the expression of CXCR4 and STAT3, both of which play an important role in tumor progression. In addition, the GBM shows considerable accumulation of resident microglia and peripheral macrophages, but polarizes differently into tumor-supporting cells. These results suggest that the intrinsic factors of GBM and their interaction with the TME determine the diffusive nature and probably the responsiveness to non-cancer cells in the TME.
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참고문헌 (31)
참고문헌 신청
안학준 / 2019 / Radiation-Induced CXCL12 Upregulation via Histone Modification at the Promoter in the Tumor Microenvironment of Hepatocellular Carcinoma / Molecules and Cells 42(7):530~545
Ahr, B. / 2005 / Identification of the cytoplasmic domains of CXCR4 involved in Jak2 and STAT3 phosphorylation / J. Biol. Chem 280:6692~6670
Allen, M. / 2016 / Origin of the U87MG glioma cell line : good news and bad news / Sci. Transl. Med 8:354re3
Armento, A. / 2017 / Molecular mechanisms of glioma cell motility / Codon Publications :73~94
Bougnaud, S. / 2016 / Molecular crosstalk between tumour and brain parenchyma instructs histopathological features in glioblastoma / Oncotarget 7:31955~31971
Ahr, B. / 2005 / Identification of the cytoplasmic domains of CXCR4 involved in Jak2 and STAT3 phosphorylation / J. Biol. Chem 280:6692~6670
Allen, M. / 2016 / Origin of the U87MG glioma cell line : good news and bad news / Sci. Transl. Med 8:354re3
Armento, A. / 2017 / Molecular mechanisms of glioma cell motility / Codon Publications :73~94
Bougnaud, S. / 2016 / Molecular crosstalk between tumour and brain parenchyma instructs histopathological features in glioblastoma / Oncotarget 7:31955~31971
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