지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 763 - 773 (11page)
이용수
초록· 키워드
오류제보하기
Recently, tumor microenvironment (TME) and its stromal constituents have provided profound insights into understanding alterations in tumor behavior. After each identification regarding the unique roles of TME compartments, non-malignant stromal cells are found to provide a sufficient tumorigenic niche for cancer cells. Of these TME constituents, adipocytes represent a dynamic population mediating endocrine effects to facilitate the crosstalk between cancer cells and distant organs, as well as the interplay with nearby tumor cells. To date, the prevalence of obesity has emphasized the significance of metabolic homeostasis along with adipose tissue (AT) inflammation, cancer incidence, and multiple pathological disorders. In this review, we summarized distinct characteristics of hypertrophic adipocytes and cancer to highlight the importance of an individual's metabolic health during cancer therapy. As AT undergoes inflammatory alterations inducing tissue remodeling, immune cell infiltration, and vascularization, these features directly influence the TME by favoring tumor progression. A comparison between inflammatory AT and progressing cancer could potentially provide crucial insights into delineating the complex communication network between uncontrolled hyperplastic tumors and their microenvironmental components. In turn, the comparison will unravel the underlying properties of dynamic tumor behavior, advocating possible therapeutic targets within TME constituents.
목차
등록된 정보가 없습니다.
참고문헌 (79)
참고문헌 신청
Greenberg, A.S. / 2006 / Obesity and the role of adipose tissue in inflammation and metabolism / Am. J. Clin. Nutr 83:461S~465S
Hawley, S. A. / 2012 / The ancient drug salicylate directly activates AMP-activated protein kinase / Science 336:918~922
He, Q. / 2011 / Regulation of HIF-1α activity in adipose tissue by obesity-associated factors : adipogenesis, insulin, and hypoxia / Am. J. Physiol. Endocrinol. Metab 300:E877~E885
Hinrichs, C. S. / 2014 / Exploiting the curative potential of adoptive T-cell therapy for cancer / Immunol. Rev 257:56~71
Hotamisligil, G. S. / 1993 / Adipose expression of tumor necrosis factor-alpha : direct role in obesity-linked insulin resistance / Science 259:87~91
Hawley, S. A. / 2012 / The ancient drug salicylate directly activates AMP-activated protein kinase / Science 336:918~922
He, Q. / 2011 / Regulation of HIF-1α activity in adipose tissue by obesity-associated factors : adipogenesis, insulin, and hypoxia / Am. J. Physiol. Endocrinol. Metab 300:E877~E885
Hinrichs, C. S. / 2014 / Exploiting the curative potential of adoptive T-cell therapy for cancer / Immunol. Rev 257:56~71
Hotamisligil, G. S. / 1993 / Adipose expression of tumor necrosis factor-alpha : direct role in obesity-linked insulin resistance / Science 259:87~91
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
A Novel Metabolic Detour for Pancreatic Cancer Survival
Molecules and Cells
2023 .06
-
CXCR4-STAT3 Axis Plays a Role in Tumor Cell Infiltration in an Orthotopic Mouse Glioblastoma Model
Molecules and Cells
2020 .01
-
비만에서 adipose tissue 호르몬에 의한 metabolic signaling
생명과학회지
2023 .03
-
암줄기세포와 종양 미세환경에 대한 고찰
생명과학회지
2024 .06
-
Molecular fossils “pseudogenes” as functional signature in biological system
Genes & Genomics
2020 .01
-
Turning Hepatic Cancer Stem Cells Inside Out ? A Deeper Understanding through Multiple Perspectives
Molecules and Cells
2015 .03
-
The impact of histone lactylation on the tumor microenvironment and metabolic pathways and its potential in cancer therapy
Genes & Genomics
2024 .09
-
The Microbiome-Immune Axis Therapeutic Effects in Cancer Treatments
Journal of Microbiology and Biotechnology
2022 .09
-
Inhibition of cell growth by cellular differentiation into adipocyte-like cells in dexamethasone sensitive cancer cell lines
Animal cells and systems
2018 .01
-
Expression of HYOU1 via Reciprocal Crosstalk between NSCLC Cells and HUVECs Control Cancer Progression and Chemoresistance in Tumor Spheroids
Molecules and Cells
2021 .01
-
암미세환경에서 종양관련대식세포의 역할
생명과학회지
2018 .08
-
Circulating Tumor DNA in a Breast Cancer Patient's Plasma Represents Driver Alterations in the Tumor Tissue
Genomics & informatics
2017 .01
-
Combined Treatment of Herbal Mixture Extract H9 with Trastuzumab Enhances Anti-tumor Growth Effect
Journal of Microbiology and Biotechnology
2015 .01
-
Nrf2 in TIME: The Emerging Role of Nuclear Factor Erythroid 2-Related Factor 2 in the Tumor Immune Microenvironment
Molecules and Cells
2023 .03
-
Comparison of the Genetic Alterations between Primary Colorectal Cancers and Their Corresponding Patient-Derived Xenograft Tissues
Genomics & informatics
2018 .01
-
Are Macrophages in Tumors Good Targets for Novel Therapeutic Approaches?
Molecules and Cells
2015 .02
-
Vascular Morphometric Changes During Tumor Growth and Chemotherapy in a Murine Mammary Tumor Model Using OCT Angiography: a Preliminary Study
Current Optics and Photonics
2019 .02
-
Association between Long-term Exposure to Particulate Matter and Cause-specific Cancer Incidence Using Cancer Screenee Cohort of the National Cancer Center in South Korea
한국대기환경학회 학술대회논문집
2023 .10
-
Distinct cellular composition between normal surgical margins and tumor tissues in oral squamous cell carcinoma
Genes & Genomics
2023 .06
-
The Tumor Therapeutic Effects of Enterotoxin-secreting Tumor Target Bacteria in a Claudin-4 Expression Tumor Models
한국미생물학회 학술대회논문집
2022 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0