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자료유형
학술저널
저자정보
저널정보
대한신경과학회 Journal of Clinical Neurology Journal of Clinical Neurology 제15권 제4호
발행연도
2019.1
수록면
448 - 453 (6page)

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Background and Purpose Various features of the cerebral cortex and white matter have been extensively investigated in migraine with aura (MwA), but the morphological characteristics of subcortical structures have been largely neglected. Te aim of this study was to identify possible differences in subcortical structures between MwA patients and healthy subjects (HS), and also to determine the correlations between the characteristics of migraine aura and the volumes of subcortical structures. Methods Tirty-two MwA patients and 32 HS matched by sex and age were analyzed in this study. Regional subcortical brain volumes were automatically calculated using the FSL/FMRIB Image Registration and Segmentation Tool sofware (https://fsl.fmrib.ox.ac.uk/fsl/fslwiki/Glossary). A general linear model analysis was used to investigate diferences in the volume of subcortical structures between the MwA patients and HS. A partial correlation test was used to assess correlations between the volume of subcortical structures and characteristics of MwA. Results Te volumes of the right globus pallidus, lef globus pallidus, and lef putamen were signifcantly smaller in MwA patients than in HS (mean±SD): 1,427±135 mm 3 vs. 1,557± 136 mm 3 (p<0.001), 1,436±126 mm 3 vs. 1,550±139 mm 3 (p=0.001), and 4,235±437 mm 3 vs. 4,522±412 mm 3 (p=0.006), respectively. Tere were no signifcant relationships between subcortical structures and clinical parameters. Conclusions Tese fndings suggest that both the globus pallidi and lef putamen play signifcant roles in the pathophysiology of the MwA. Future studies should determine the cause-and-effect relationships, since these could not be discriminated in this study due to its cross-sectional design.

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