지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 558 - 564 (7page)
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초록· 키워드
오류제보하기
Objective Synaptic vesicle mobilization and neurite outgrowth regulation molecules were examined in modulation of effects of methylphenidate (MPH) in Spontaneous Hypertensive Rats (SHRs), a model for attention-deficit hyperactivity disorder (ADHD). Methods We compared the changes in the protein expression level of Cyclin dependent kinase 5 (Cdk5) and molecular substrates of Cdk5; tropomyosin receptor kinase B (TrkB), syntaxin 1A (STX1A) and synaptosomal-associated protein 25 (SNAP25). Comparisons were made in prefrontal cortex of vehicle (distilled water i.p. for 7 days)-treated SHRs, vehicle-treated Wistar Kyoto Rats (WKYs) and MPH (2 mg/kg i.p. for 7 days) treated SHRs. Results The Cdk5 level of vehicle-treated SHRs was significantly decreased compared to the Cdk5 level of vehicle-treated WKY rats, but was restored to the expression level of vehicle-treated WKYs in MPH-treated SHR. The ratio of p25/p35 was significantly decreased in MPH-treated SHR compared to vehicle-treated SHR. Moreover, TrkB, STX1A and SNAP25 of vehicle-treated SHRs were significantly decreased compared to vehicle-treated WKY rats, but were restored to the expression level of vehicle-treated WKYs in MPH-treated SHR. Conclusion The results show that Cdk5, TrkB, STX1A, and SNAP25 were involved in the modulation of MPH effects in prefrontal cortex of SHRs and play important role in treatment of ADHD.
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등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
Limbers CA / 2011 / A comparative analysis of health-related quality of life and family impact between children with ADHD treated in a general pediatric clinic and a psychiatric clinic utilizing the PedsQL / J Atten Disord 15:392~402
Froehlich TE / 2007 / Prevalence, recognition, and treatment of attention-deficit/hyperactivity disorder in a national sample of US children / Arch Pediatr Adolesc Med 161:857~864
Okamoto K / 1963 / Development of a strain of spontaneously hypertensive rats / Jpn Circ J 27:282~293
Miller EM / 2012 / The spontaneously hypertensive and Wistar Kyoto rat models of ADHD exhibit sub-regional differences in dopamine release and uptake in the striatum and nucleus accumbens / Neuropharmacology 63:1327~1334
Russell VA / 2011 / Overview of animal models of attention deficit hyperactivity disorder (ADHD) / Curr Protoc Neurosci Chapter 9(Unit9):35
Froehlich TE / 2007 / Prevalence, recognition, and treatment of attention-deficit/hyperactivity disorder in a national sample of US children / Arch Pediatr Adolesc Med 161:857~864
Okamoto K / 1963 / Development of a strain of spontaneously hypertensive rats / Jpn Circ J 27:282~293
Miller EM / 2012 / The spontaneously hypertensive and Wistar Kyoto rat models of ADHD exhibit sub-regional differences in dopamine release and uptake in the striatum and nucleus accumbens / Neuropharmacology 63:1327~1334
Russell VA / 2011 / Overview of animal models of attention deficit hyperactivity disorder (ADHD) / Curr Protoc Neurosci Chapter 9(Unit9):35
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