지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.7
- 수록면
- 154 - 160 (7page)
이용수
초록· 키워드
오류제보하기
Objectives: It remains unclear whether methylphenidate (MPH) has yadverse effects on growth in children. This study aimed to investigate the association of MPH with serum biological markers of growth in children with attention-deficit/hyperactivity disorder (ADHD).
Methods: The present study included 103 children with ADHD (64 drug-naive children, 39 MPH-treated children) and 112 control subjects. Children with ADHD were diagnosed on the basis of a semi-structured interview. Levels of biochemical markers of growth, including insulin-like growth factor-I, thyroid stimulating hormone (TSH), free T4, calcium, phosphorus, alkaline phosphatase, vitamin D, hemoglobin, total protein, albumin, total cholesterol, and hematocrit were measured in these individuals.
Results: Except in case of TSH, no intergroup differences were found in the levels of the growth markers. The levels of TSH were found to be lower in the MPH-treated boys with ADHD than in the drug-naive and control groups (p<0.05), although the levels of TSH in all the groups were within normal limits.
Conclusion: In this cross-sectional study, no significant association was found between MPH and growth markers. This calls for the need to carry out prospective longitudinal research studies in the future that investigate the effect of MPH on the growth trajectory in children.
Methods: The present study included 103 children with ADHD (64 drug-naive children, 39 MPH-treated children) and 112 control subjects. Children with ADHD were diagnosed on the basis of a semi-structured interview. Levels of biochemical markers of growth, including insulin-like growth factor-I, thyroid stimulating hormone (TSH), free T4, calcium, phosphorus, alkaline phosphatase, vitamin D, hemoglobin, total protein, albumin, total cholesterol, and hematocrit were measured in these individuals.
Results: Except in case of TSH, no intergroup differences were found in the levels of the growth markers. The levels of TSH were found to be lower in the MPH-treated boys with ADHD than in the drug-naive and control groups (p<0.05), although the levels of TSH in all the groups were within normal limits.
Conclusion: In this cross-sectional study, no significant association was found between MPH and growth markers. This calls for the need to carry out prospective longitudinal research studies in the future that investigate the effect of MPH on the growth trajectory in children.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
CONCLUSION
REFERENCES
참고문헌 (25)
참고문헌 신청
Greenhill LL / 2002 / Practice parameter for the use of stimulant medications in the treatment of children, adolescents, and adults / J Am Acad Child Adolesc Psychiatry 41(2 Suppl):26S~49S
Lisska MC / 2003 / Daily methylphenidate use slows the growth of children : a community based study / J Pediatr Endocrinol Metab 16:711~718
Swanson J / 2006 / Stimulant-related reductions of growth rates in the PATS / J Am Acad Child Adolesc Psychiatry 45:1304~1313
Kang KD / 2016 / Effects of methylphenidate on body index and physical fitness in Korean children with attention deficit hyperactivity disorder / Hum Psychopharmacol 31:76~82
Spencer TJ / 2006 / Does prolonged therapy with a long-acting stimulant suppress growth in children with ADHD? / J Am Acad Child Adolesc Psychiatry 45:527~537
Lisska MC / 2003 / Daily methylphenidate use slows the growth of children : a community based study / J Pediatr Endocrinol Metab 16:711~718
Swanson J / 2006 / Stimulant-related reductions of growth rates in the PATS / J Am Acad Child Adolesc Psychiatry 45:1304~1313
Kang KD / 2016 / Effects of methylphenidate on body index and physical fitness in Korean children with attention deficit hyperactivity disorder / Hum Psychopharmacol 31:76~82
Spencer TJ / 2006 / Does prolonged therapy with a long-acting stimulant suppress growth in children with ADHD? / J Am Acad Child Adolesc Psychiatry 45:527~537
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